Abstract
OBJECTIVE: Negative-pressure wound therapy (NPWT) has become a common wound care treatment modality for a variety of wounds. Several previous studies have reported that NPWT increases blood flow in the wound bed. However, NPWT might decrease tissue oxygenation in the wound bed because the foam sponge of NPWT compresses the wound bed under the influence of the applied negative pressure. Adequate tissue oxygenation is an essential consideration during diabetic foot management, and the foot is more sensitive to ischemia than any other region. Furthermore, the issue as to whether NPWT reduces or increases tissue oxygenation in diabetic feet has never been correctly addressed. The aim of this study was to evaluate the influence of NPWT on tissue oxygenation in diabetic feet. PARTICIPANTS: Transcutaneous partial oxygen pressures (TcPo2) were measured to determine tissue oxygenation levels beneath NPWT dressings on 21 feet of 21 diabetic foot ulcer patients. DESIGN: A TcPo2 sensor was fixed at the tarsometatarsal area of contralateral unwounded feet. A suction pressure of-125 mm Hg was applied until TcPo2 reached a steady state. The TcPo2 values for diabetic feet were measured before, during, and after NPWT. MAIN RESULTS: The TcPo2 levels decreased significantly after applying NPWT in all patients. Mean TcPo2 values before, during, and after therapy were 44.6 (SD, 15.2), 6.0 (SD, 7.1), and 40.3 (SD, 16.4) mm Hg (P <.01), respectively. CONCLUSION: These results show that NPWT significantly reduces tissue oxygenation levels in diabetic feet.
| Original language | English |
|---|---|
| Pages (from-to) | 364-370 |
| Number of pages | 7 |
| Journal | Advances in Skin and Wound Care |
| Volume | 29 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2016 Aug 1 |
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Keywords
- diabetic foot
- negative-pressure wound therapy
- tissue oxygenation
ASJC Scopus subject areas
- Dermatology
- Advanced and Specialised Nursing
Cite this
Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet. / Jung, Jae A.; Yoo, Ki Hyun; Han, Seung-Kyu; Lee, Ye Na; Jeong, Seong-Ho; Dhong, Eun-Sang; Kim, Woo-Kyung.
In: Advances in Skin and Wound Care, Vol. 29, No. 8, 01.08.2016, p. 364-370.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet
AU - Jung, Jae A.
AU - Yoo, Ki Hyun
AU - Han, Seung-Kyu
AU - Lee, Ye Na
AU - Jeong, Seong-Ho
AU - Dhong, Eun-Sang
AU - Kim, Woo-Kyung
PY - 2016/8/1
Y1 - 2016/8/1
N2 - OBJECTIVE: Negative-pressure wound therapy (NPWT) has become a common wound care treatment modality for a variety of wounds. Several previous studies have reported that NPWT increases blood flow in the wound bed. However, NPWT might decrease tissue oxygenation in the wound bed because the foam sponge of NPWT compresses the wound bed under the influence of the applied negative pressure. Adequate tissue oxygenation is an essential consideration during diabetic foot management, and the foot is more sensitive to ischemia than any other region. Furthermore, the issue as to whether NPWT reduces or increases tissue oxygenation in diabetic feet has never been correctly addressed. The aim of this study was to evaluate the influence of NPWT on tissue oxygenation in diabetic feet. PARTICIPANTS: Transcutaneous partial oxygen pressures (TcPo2) were measured to determine tissue oxygenation levels beneath NPWT dressings on 21 feet of 21 diabetic foot ulcer patients. DESIGN: A TcPo2 sensor was fixed at the tarsometatarsal area of contralateral unwounded feet. A suction pressure of-125 mm Hg was applied until TcPo2 reached a steady state. The TcPo2 values for diabetic feet were measured before, during, and after NPWT. MAIN RESULTS: The TcPo2 levels decreased significantly after applying NPWT in all patients. Mean TcPo2 values before, during, and after therapy were 44.6 (SD, 15.2), 6.0 (SD, 7.1), and 40.3 (SD, 16.4) mm Hg (P <.01), respectively. CONCLUSION: These results show that NPWT significantly reduces tissue oxygenation levels in diabetic feet.
AB - OBJECTIVE: Negative-pressure wound therapy (NPWT) has become a common wound care treatment modality for a variety of wounds. Several previous studies have reported that NPWT increases blood flow in the wound bed. However, NPWT might decrease tissue oxygenation in the wound bed because the foam sponge of NPWT compresses the wound bed under the influence of the applied negative pressure. Adequate tissue oxygenation is an essential consideration during diabetic foot management, and the foot is more sensitive to ischemia than any other region. Furthermore, the issue as to whether NPWT reduces or increases tissue oxygenation in diabetic feet has never been correctly addressed. The aim of this study was to evaluate the influence of NPWT on tissue oxygenation in diabetic feet. PARTICIPANTS: Transcutaneous partial oxygen pressures (TcPo2) were measured to determine tissue oxygenation levels beneath NPWT dressings on 21 feet of 21 diabetic foot ulcer patients. DESIGN: A TcPo2 sensor was fixed at the tarsometatarsal area of contralateral unwounded feet. A suction pressure of-125 mm Hg was applied until TcPo2 reached a steady state. The TcPo2 values for diabetic feet were measured before, during, and after NPWT. MAIN RESULTS: The TcPo2 levels decreased significantly after applying NPWT in all patients. Mean TcPo2 values before, during, and after therapy were 44.6 (SD, 15.2), 6.0 (SD, 7.1), and 40.3 (SD, 16.4) mm Hg (P <.01), respectively. CONCLUSION: These results show that NPWT significantly reduces tissue oxygenation levels in diabetic feet.
KW - diabetic foot
KW - negative-pressure wound therapy
KW - tissue oxygenation
UR - http://www.scopus.com/inward/record.url?scp=84979623353&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84979623353&partnerID=8YFLogxK
U2 - 10.1097/01.ASW.0000483038.18331.a4
DO - 10.1097/01.ASW.0000483038.18331.a4
M3 - Article
C2 - 27429242
AN - SCOPUS:84979623353
VL - 29
SP - 364
EP - 370
JO - Advances in Skin and Wound Care
JF - Advances in Skin and Wound Care
SN - 1527-7941
IS - 8
ER -