Influence of paradoxical sleep deprivation and sleep recovery on testosterone level in rats of different ages

Mi-Mi Oh, Jin Wook Kim, Myeong Heon Jin, Je-Jong Kim, Du Geon Moon

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This study was performed to assess serum testosterone alterations induced by paradoxical sleep deprivation (PSD) and to verify their attenuation during sleep recovery (SR) based on different durations and ages. Wistar male rats aged 12 weeks for the younger group and 20 weeks for the elder group were randomly distributed into one of the following groups: a control group (cage and platform), 3-day SD, 5-day SD, 7-day SD, 1-day SR, 3-day SR and 5-day SR groups. For PSD, the modified multiple platform method was used to specifically limit rapid eye movement (REM) sleep. Differences in the testosterone and luteinizing hormone levels between the younger group and the elder group according to duration of PSD and SR recovery were analysed. Testosterone continued to fall during the sleep deprivation period in a time-dependent manner in both the younger (P0.001, correlation coefficient r0.651) and elder groups (P0.001, correlation coefficient r0.840). The elder group showed a significantly lower level of testosterone compared with the younger group after PSD. Upon SR after 3 days of PSD, the testosterone level continued to rise for 5 days after sleep recovery in the younger group (P0.013), whereas testosterone concentrations failed to recover until day 5 in the elder group. PSD caused a more detrimental effect on serum testosterone in the elder group compared to the younger group with respect to decreases in luteinizing hormone (LH) levels. The replenishment of serum testosterone level was prohibited in the elder group suggesting that the effects of SD/SR may be age-dependent. The mechanism by which SD affects serum testosterone and how age may modify the process are still unclear.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalAsian Journal of Andrology
Volume14
Issue number2
DOIs
Publication statusPublished - 2012 Mar 1

Fingerprint

Sleep Deprivation
REM Sleep
Testosterone
Sleep
Luteinizing Hormone
Serum
Wistar Rats
Control Groups

Keywords

  • luteinizing hormone
  • paradoxical sleep deprivation
  • recovery
  • testosterone

ASJC Scopus subject areas

  • Urology

Cite this

Influence of paradoxical sleep deprivation and sleep recovery on testosterone level in rats of different ages. / Oh, Mi-Mi; Kim, Jin Wook; Jin, Myeong Heon; Kim, Je-Jong; Moon, Du Geon.

In: Asian Journal of Andrology, Vol. 14, No. 2, 01.03.2012, p. 330-334.

Research output: Contribution to journalArticle

@article{97f3321c81e54b239df157d010c1e793,
title = "Influence of paradoxical sleep deprivation and sleep recovery on testosterone level in rats of different ages",
abstract = "This study was performed to assess serum testosterone alterations induced by paradoxical sleep deprivation (PSD) and to verify their attenuation during sleep recovery (SR) based on different durations and ages. Wistar male rats aged 12 weeks for the younger group and 20 weeks for the elder group were randomly distributed into one of the following groups: a control group (cage and platform), 3-day SD, 5-day SD, 7-day SD, 1-day SR, 3-day SR and 5-day SR groups. For PSD, the modified multiple platform method was used to specifically limit rapid eye movement (REM) sleep. Differences in the testosterone and luteinizing hormone levels between the younger group and the elder group according to duration of PSD and SR recovery were analysed. Testosterone continued to fall during the sleep deprivation period in a time-dependent manner in both the younger (P0.001, correlation coefficient r0.651) and elder groups (P0.001, correlation coefficient r0.840). The elder group showed a significantly lower level of testosterone compared with the younger group after PSD. Upon SR after 3 days of PSD, the testosterone level continued to rise for 5 days after sleep recovery in the younger group (P0.013), whereas testosterone concentrations failed to recover until day 5 in the elder group. PSD caused a more detrimental effect on serum testosterone in the elder group compared to the younger group with respect to decreases in luteinizing hormone (LH) levels. The replenishment of serum testosterone level was prohibited in the elder group suggesting that the effects of SD/SR may be age-dependent. The mechanism by which SD affects serum testosterone and how age may modify the process are still unclear.",
keywords = "luteinizing hormone, paradoxical sleep deprivation, recovery, testosterone",
author = "Mi-Mi Oh and Kim, {Jin Wook} and Jin, {Myeong Heon} and Je-Jong Kim and Moon, {Du Geon}",
year = "2012",
month = "3",
day = "1",
doi = "10.1038/aja.2011.153",
language = "English",
volume = "14",
pages = "330--334",
journal = "Asian Journal of Andrology",
issn = "1008-682X",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Influence of paradoxical sleep deprivation and sleep recovery on testosterone level in rats of different ages

AU - Oh, Mi-Mi

AU - Kim, Jin Wook

AU - Jin, Myeong Heon

AU - Kim, Je-Jong

AU - Moon, Du Geon

PY - 2012/3/1

Y1 - 2012/3/1

N2 - This study was performed to assess serum testosterone alterations induced by paradoxical sleep deprivation (PSD) and to verify their attenuation during sleep recovery (SR) based on different durations and ages. Wistar male rats aged 12 weeks for the younger group and 20 weeks for the elder group were randomly distributed into one of the following groups: a control group (cage and platform), 3-day SD, 5-day SD, 7-day SD, 1-day SR, 3-day SR and 5-day SR groups. For PSD, the modified multiple platform method was used to specifically limit rapid eye movement (REM) sleep. Differences in the testosterone and luteinizing hormone levels between the younger group and the elder group according to duration of PSD and SR recovery were analysed. Testosterone continued to fall during the sleep deprivation period in a time-dependent manner in both the younger (P0.001, correlation coefficient r0.651) and elder groups (P0.001, correlation coefficient r0.840). The elder group showed a significantly lower level of testosterone compared with the younger group after PSD. Upon SR after 3 days of PSD, the testosterone level continued to rise for 5 days after sleep recovery in the younger group (P0.013), whereas testosterone concentrations failed to recover until day 5 in the elder group. PSD caused a more detrimental effect on serum testosterone in the elder group compared to the younger group with respect to decreases in luteinizing hormone (LH) levels. The replenishment of serum testosterone level was prohibited in the elder group suggesting that the effects of SD/SR may be age-dependent. The mechanism by which SD affects serum testosterone and how age may modify the process are still unclear.

AB - This study was performed to assess serum testosterone alterations induced by paradoxical sleep deprivation (PSD) and to verify their attenuation during sleep recovery (SR) based on different durations and ages. Wistar male rats aged 12 weeks for the younger group and 20 weeks for the elder group were randomly distributed into one of the following groups: a control group (cage and platform), 3-day SD, 5-day SD, 7-day SD, 1-day SR, 3-day SR and 5-day SR groups. For PSD, the modified multiple platform method was used to specifically limit rapid eye movement (REM) sleep. Differences in the testosterone and luteinizing hormone levels between the younger group and the elder group according to duration of PSD and SR recovery were analysed. Testosterone continued to fall during the sleep deprivation period in a time-dependent manner in both the younger (P0.001, correlation coefficient r0.651) and elder groups (P0.001, correlation coefficient r0.840). The elder group showed a significantly lower level of testosterone compared with the younger group after PSD. Upon SR after 3 days of PSD, the testosterone level continued to rise for 5 days after sleep recovery in the younger group (P0.013), whereas testosterone concentrations failed to recover until day 5 in the elder group. PSD caused a more detrimental effect on serum testosterone in the elder group compared to the younger group with respect to decreases in luteinizing hormone (LH) levels. The replenishment of serum testosterone level was prohibited in the elder group suggesting that the effects of SD/SR may be age-dependent. The mechanism by which SD affects serum testosterone and how age may modify the process are still unclear.

KW - luteinizing hormone

KW - paradoxical sleep deprivation

KW - recovery

KW - testosterone

UR - http://www.scopus.com/inward/record.url?scp=84863269641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863269641&partnerID=8YFLogxK

U2 - 10.1038/aja.2011.153

DO - 10.1038/aja.2011.153

M3 - Article

C2 - 22157981

AN - SCOPUS:84863269641

VL - 14

SP - 330

EP - 334

JO - Asian Journal of Andrology

JF - Asian Journal of Andrology

SN - 1008-682X

IS - 2

ER -