Influence of Peripheral Neuropathy and Microangiopathy on Skin Hydration in the Feet of Patients With Diabetes Mellitus

Sik Namgoong, Jong Phil Yang, Seung-Kyu Han, Ye Na Lee, Eun-Sang Dhong

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Maintaining adequate skin hydration is crucial in the feet of patients with diabetes because xerotic skin may crack and develop fissures, thereby increasing vulnerability to ulceration and infection. The nervous system is considered the powerhouse for maintaining adequate skin hydration; however, no clinical study has assessed the effect of the nervous system on skin hydration. In addition, it is hypothesized that microcirculation may play an important role in maintaining adequate hydration in patients with diabetes. OBJECTIVE: This study aims to evaluate the influence of peripheral nerve function and microvascularity on skin hydration in the feet of patients with diabetes mellitus and compare the effects of these 2 functions on skin hydration. MATERIALS AND METHODS: This study included 266 patients with diabetic foot disease. Skin hydration was evaluated using corneometry and microvascularity by measuring the transcutaneous oximetry (TcpO₂) of the foot. The Semmes-Weinstein 5.07/10-g monofilament test, electromyography, and nerve conduction velocity test were conducted to evaluate peripheral neuropathy. Patient data were divided into 3 subgroups according to test values, and statistical comparisons were performed using the linear-by-linear association trend and Pearson's chi-square tests. RESULTS: There was a significant correlation between skin hydration and TcpO₂. However, there was no significant correlation between skin hydration and peripheral nerve function (P = .338). CONCLUSIONS: The results of this study demonstrated that skin hydration in the feet of patients with diabetes mellitus mainly is influenced by microcirculation rather than peripheral nerve function.

Original languageEnglish
Pages (from-to)173-178
Number of pages6
JournalWounds : a compendium of clinical research and practice
Volume31
Issue number7
Publication statusPublished - 2019 Jul 1

Fingerprint

Peripheral Nervous System Diseases
Foot
Diabetes Mellitus
Skin
Peripheral Nerves
Microcirculation
Nervous System
Transcutaneous Blood Gas Monitoring
Foot Diseases
Diabetic Foot
Neural Conduction
Electromyography
Chi-Square Distribution

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

Cite this

Influence of Peripheral Neuropathy and Microangiopathy on Skin Hydration in the Feet of Patients With Diabetes Mellitus. / Namgoong, Sik; Yang, Jong Phil; Han, Seung-Kyu; Lee, Ye Na; Dhong, Eun-Sang.

In: Wounds : a compendium of clinical research and practice, Vol. 31, No. 7, 01.07.2019, p. 173-178.

Research output: Contribution to journalArticle

@article{497d6fcf72294ebcae9551921a3492eb,
title = "Influence of Peripheral Neuropathy and Microangiopathy on Skin Hydration in the Feet of Patients With Diabetes Mellitus",
abstract = "INTRODUCTION: Maintaining adequate skin hydration is crucial in the feet of patients with diabetes because xerotic skin may crack and develop fissures, thereby increasing vulnerability to ulceration and infection. The nervous system is considered the powerhouse for maintaining adequate skin hydration; however, no clinical study has assessed the effect of the nervous system on skin hydration. In addition, it is hypothesized that microcirculation may play an important role in maintaining adequate hydration in patients with diabetes. OBJECTIVE: This study aims to evaluate the influence of peripheral nerve function and microvascularity on skin hydration in the feet of patients with diabetes mellitus and compare the effects of these 2 functions on skin hydration. MATERIALS AND METHODS: This study included 266 patients with diabetic foot disease. Skin hydration was evaluated using corneometry and microvascularity by measuring the transcutaneous oximetry (TcpO₂) of the foot. The Semmes-Weinstein 5.07/10-g monofilament test, electromyography, and nerve conduction velocity test were conducted to evaluate peripheral neuropathy. Patient data were divided into 3 subgroups according to test values, and statistical comparisons were performed using the linear-by-linear association trend and Pearson's chi-square tests. RESULTS: There was a significant correlation between skin hydration and TcpO₂. However, there was no significant correlation between skin hydration and peripheral nerve function (P = .338). CONCLUSIONS: The results of this study demonstrated that skin hydration in the feet of patients with diabetes mellitus mainly is influenced by microcirculation rather than peripheral nerve function.",
author = "Sik Namgoong and Yang, {Jong Phil} and Seung-Kyu Han and Lee, {Ye Na} and Eun-Sang Dhong",
year = "2019",
month = "7",
day = "1",
language = "English",
volume = "31",
pages = "173--178",
journal = "Wounds",
issn = "1044-7946",
publisher = "HMP Communications",
number = "7",

}

TY - JOUR

T1 - Influence of Peripheral Neuropathy and Microangiopathy on Skin Hydration in the Feet of Patients With Diabetes Mellitus

AU - Namgoong, Sik

AU - Yang, Jong Phil

AU - Han, Seung-Kyu

AU - Lee, Ye Na

AU - Dhong, Eun-Sang

PY - 2019/7/1

Y1 - 2019/7/1

N2 - INTRODUCTION: Maintaining adequate skin hydration is crucial in the feet of patients with diabetes because xerotic skin may crack and develop fissures, thereby increasing vulnerability to ulceration and infection. The nervous system is considered the powerhouse for maintaining adequate skin hydration; however, no clinical study has assessed the effect of the nervous system on skin hydration. In addition, it is hypothesized that microcirculation may play an important role in maintaining adequate hydration in patients with diabetes. OBJECTIVE: This study aims to evaluate the influence of peripheral nerve function and microvascularity on skin hydration in the feet of patients with diabetes mellitus and compare the effects of these 2 functions on skin hydration. MATERIALS AND METHODS: This study included 266 patients with diabetic foot disease. Skin hydration was evaluated using corneometry and microvascularity by measuring the transcutaneous oximetry (TcpO₂) of the foot. The Semmes-Weinstein 5.07/10-g monofilament test, electromyography, and nerve conduction velocity test were conducted to evaluate peripheral neuropathy. Patient data were divided into 3 subgroups according to test values, and statistical comparisons were performed using the linear-by-linear association trend and Pearson's chi-square tests. RESULTS: There was a significant correlation between skin hydration and TcpO₂. However, there was no significant correlation between skin hydration and peripheral nerve function (P = .338). CONCLUSIONS: The results of this study demonstrated that skin hydration in the feet of patients with diabetes mellitus mainly is influenced by microcirculation rather than peripheral nerve function.

AB - INTRODUCTION: Maintaining adequate skin hydration is crucial in the feet of patients with diabetes because xerotic skin may crack and develop fissures, thereby increasing vulnerability to ulceration and infection. The nervous system is considered the powerhouse for maintaining adequate skin hydration; however, no clinical study has assessed the effect of the nervous system on skin hydration. In addition, it is hypothesized that microcirculation may play an important role in maintaining adequate hydration in patients with diabetes. OBJECTIVE: This study aims to evaluate the influence of peripheral nerve function and microvascularity on skin hydration in the feet of patients with diabetes mellitus and compare the effects of these 2 functions on skin hydration. MATERIALS AND METHODS: This study included 266 patients with diabetic foot disease. Skin hydration was evaluated using corneometry and microvascularity by measuring the transcutaneous oximetry (TcpO₂) of the foot. The Semmes-Weinstein 5.07/10-g monofilament test, electromyography, and nerve conduction velocity test were conducted to evaluate peripheral neuropathy. Patient data were divided into 3 subgroups according to test values, and statistical comparisons were performed using the linear-by-linear association trend and Pearson's chi-square tests. RESULTS: There was a significant correlation between skin hydration and TcpO₂. However, there was no significant correlation between skin hydration and peripheral nerve function (P = .338). CONCLUSIONS: The results of this study demonstrated that skin hydration in the feet of patients with diabetes mellitus mainly is influenced by microcirculation rather than peripheral nerve function.

UR - http://www.scopus.com/inward/record.url?scp=85069949209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069949209&partnerID=8YFLogxK

M3 - Article

C2 - 31184593

AN - SCOPUS:85069949209

VL - 31

SP - 173

EP - 178

JO - Wounds

JF - Wounds

SN - 1044-7946

IS - 7

ER -