Abstract
Objective: To investigate the influence of pregnancy on patients with neuromyelitis optica spectrum disorder (NMOSD). Methods: A total of 190 women with NMOSD were enrolled from 7 referral hospitals in 4 countries. We reviewed medical records and used a structured questionnaire to investigate gravidity, parity, and the number of relapses during the 2 years before pregnancy, during each trimester of pregnancy, during the first and second trimesters after delivery, and for 6 months thereafter. The annualized relapse rate (ARR) was calculated for each period. Results: Of the 190 women with NMOSD, 40 patients experienced 54 informative pregnancies, and all of them were seropositive for aquaporin-4 antibody. Fourteen patients developed the first symptoms of NMOSD either during the pregnancy (3 patients) or within a year after delivery or abortion (8 and 3 patients, respectively). Twenty-six patients experienced 40 pregnancies after the onset of NMOSD (26 deliveries and 14 abortions [1 spontaneous and 13 elective]). There was one preterm delivery with birth defects and no stillbirths. The ARR during pregnancy did not differ from that before pregnancy, but it increased significantly during the first and second trimesters after delivery (5.3 and 3.7 times, respectively). Moreover,77%of the deliveries were associated with postpartum relapses. Conclusion: The significantly increased relapse rate and numerous cases of NMOSD onset after pregnancy suggest that delivery adversely affects the course of NMOSD. Prospective studies are needed to confirm our findings.
| Original language | English |
|---|---|
| Pages (from-to) | 1264-1267 |
| Number of pages | 4 |
| Journal | Neurology |
| Volume | 78 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 2012 Apr 17 |
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ASJC Scopus subject areas
- Clinical Neurology
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Influence of pregnancy on neuromyelitis optica spectrum disorder. / Kim, W.; Kim, S. H.; Nakashima, I.; Takai, Y.; Fujihara, K.; Leite, M. I.; Kitley, J.; Palace, J.; Santos, E.; Coutinho, E.; Silva, A. M.; Kim, Byoung Joon; Kim, Byung Jo; Ahn, S. W.; Kim, H. J.
In: Neurology, Vol. 78, No. 16, 17.04.2012, p. 1264-1267.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Influence of pregnancy on neuromyelitis optica spectrum disorder
AU - Kim, W.
AU - Kim, S. H.
AU - Nakashima, I.
AU - Takai, Y.
AU - Fujihara, K.
AU - Leite, M. I.
AU - Kitley, J.
AU - Palace, J.
AU - Santos, E.
AU - Coutinho, E.
AU - Silva, A. M.
AU - Kim, Byoung Joon
AU - Kim, Byung Jo
AU - Ahn, S. W.
AU - Kim, H. J.
PY - 2012/4/17
Y1 - 2012/4/17
N2 - Objective: To investigate the influence of pregnancy on patients with neuromyelitis optica spectrum disorder (NMOSD). Methods: A total of 190 women with NMOSD were enrolled from 7 referral hospitals in 4 countries. We reviewed medical records and used a structured questionnaire to investigate gravidity, parity, and the number of relapses during the 2 years before pregnancy, during each trimester of pregnancy, during the first and second trimesters after delivery, and for 6 months thereafter. The annualized relapse rate (ARR) was calculated for each period. Results: Of the 190 women with NMOSD, 40 patients experienced 54 informative pregnancies, and all of them were seropositive for aquaporin-4 antibody. Fourteen patients developed the first symptoms of NMOSD either during the pregnancy (3 patients) or within a year after delivery or abortion (8 and 3 patients, respectively). Twenty-six patients experienced 40 pregnancies after the onset of NMOSD (26 deliveries and 14 abortions [1 spontaneous and 13 elective]). There was one preterm delivery with birth defects and no stillbirths. The ARR during pregnancy did not differ from that before pregnancy, but it increased significantly during the first and second trimesters after delivery (5.3 and 3.7 times, respectively). Moreover,77%of the deliveries were associated with postpartum relapses. Conclusion: The significantly increased relapse rate and numerous cases of NMOSD onset after pregnancy suggest that delivery adversely affects the course of NMOSD. Prospective studies are needed to confirm our findings.
AB - Objective: To investigate the influence of pregnancy on patients with neuromyelitis optica spectrum disorder (NMOSD). Methods: A total of 190 women with NMOSD were enrolled from 7 referral hospitals in 4 countries. We reviewed medical records and used a structured questionnaire to investigate gravidity, parity, and the number of relapses during the 2 years before pregnancy, during each trimester of pregnancy, during the first and second trimesters after delivery, and for 6 months thereafter. The annualized relapse rate (ARR) was calculated for each period. Results: Of the 190 women with NMOSD, 40 patients experienced 54 informative pregnancies, and all of them were seropositive for aquaporin-4 antibody. Fourteen patients developed the first symptoms of NMOSD either during the pregnancy (3 patients) or within a year after delivery or abortion (8 and 3 patients, respectively). Twenty-six patients experienced 40 pregnancies after the onset of NMOSD (26 deliveries and 14 abortions [1 spontaneous and 13 elective]). There was one preterm delivery with birth defects and no stillbirths. The ARR during pregnancy did not differ from that before pregnancy, but it increased significantly during the first and second trimesters after delivery (5.3 and 3.7 times, respectively). Moreover,77%of the deliveries were associated with postpartum relapses. Conclusion: The significantly increased relapse rate and numerous cases of NMOSD onset after pregnancy suggest that delivery adversely affects the course of NMOSD. Prospective studies are needed to confirm our findings.
UR - http://www.scopus.com/inward/record.url?scp=84860708188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860708188&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e318250d812
DO - 10.1212/WNL.0b013e318250d812
M3 - Review article
C2 - 22491862
AN - SCOPUS:84860708188
VL - 78
SP - 1264
EP - 1267
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 16
ER -