Influence of sex on the association between epicardial adipose tissue and left atrial transport function in patients with atrial fibrillation: A multislice computed tomography study

Jin-Seok Kim, Seung Yong Shin, Jun Hyuk Kang, Hwan-Seok Yong, Jin Oh Na, Cheol Ung Choi, Seong Hwan Kim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Chun Hwang, Young Hoon Kim, Hong Euy Lim

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4 Citations (Scopus)

Abstract

Background--Epicardial adipose tissue (EAT) is known to play an important role in atrial fibrillation substrate remodeling; however, the influence of sex on the association between EAT and left atrial (LA) transport function has not been elucidated. Methods and Results--Of the 514 patients who underwent an index atrial fibrillation ablation procedure, 123 postmenopausal women with no history of hormone replacement therapy and 123 men who were matched for age, body mass index, type of atrial fibrillation, and CHADS2 score were enrolled. Before the procedure, LA volume, LA emptying fraction, and EAT volume were assessed using multislice computed tomography. Blood samples were obtained from a coronary sinus for analysis of serum adiponectin level before the ablation procedure. There were no differences in baseline demographics and laboratory findings between sexes. Compared with men, women had significantly less total EAT (P < 0.001) and higher serum adiponectin levels (P=0.022) but higher proportions of periatrial EAT to total EAT volume (P/T EAT ratio, P < 0.001), lower LA emptying fraction (P=0.042), and lower LA voltage (P=0.034). The ratio of periatrial to total EAT volume correlated significantly with LA emptying fraction and LA voltage in both sexes, whereas total EAT volume and serum adiponectin level did not. On multivariate analysis, increased LA volume and higher periatrial:total EAT volume ratio were independent predictors of decreased LA emptying fraction in both sexes. Conclusions--Compared with matched men, postmenopausal women with atrial fibrillation had higher periatrial adiposity, which was independently correlated with decreased LA voltage and LA transport function.

Original languageEnglish
Article numbere006077
JournalJournal of the American Heart Association
Volume6
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

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Left Atrial Function
Multidetector Computed Tomography
Atrial Fibrillation
Adipose Tissue
Adiponectin
Serum
Coronary Sinus
Hormone Replacement Therapy
Adiposity
Body Mass Index
Multivariate Analysis

Keywords

  • Atrial fibrillation
  • Computed tomography
  • Epicardial fat
  • Left atrial function
  • Sex differences

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{f6dec5d5e999468185b56afd7b78e45e,
title = "Influence of sex on the association between epicardial adipose tissue and left atrial transport function in patients with atrial fibrillation: A multislice computed tomography study",
abstract = "Background--Epicardial adipose tissue (EAT) is known to play an important role in atrial fibrillation substrate remodeling; however, the influence of sex on the association between EAT and left atrial (LA) transport function has not been elucidated. Methods and Results--Of the 514 patients who underwent an index atrial fibrillation ablation procedure, 123 postmenopausal women with no history of hormone replacement therapy and 123 men who were matched for age, body mass index, type of atrial fibrillation, and CHADS2 score were enrolled. Before the procedure, LA volume, LA emptying fraction, and EAT volume were assessed using multislice computed tomography. Blood samples were obtained from a coronary sinus for analysis of serum adiponectin level before the ablation procedure. There were no differences in baseline demographics and laboratory findings between sexes. Compared with men, women had significantly less total EAT (P < 0.001) and higher serum adiponectin levels (P=0.022) but higher proportions of periatrial EAT to total EAT volume (P/T EAT ratio, P < 0.001), lower LA emptying fraction (P=0.042), and lower LA voltage (P=0.034). The ratio of periatrial to total EAT volume correlated significantly with LA emptying fraction and LA voltage in both sexes, whereas total EAT volume and serum adiponectin level did not. On multivariate analysis, increased LA volume and higher periatrial:total EAT volume ratio were independent predictors of decreased LA emptying fraction in both sexes. Conclusions--Compared with matched men, postmenopausal women with atrial fibrillation had higher periatrial adiposity, which was independently correlated with decreased LA voltage and LA transport function.",
keywords = "Atrial fibrillation, Computed tomography, Epicardial fat, Left atrial function, Sex differences",
author = "Jin-Seok Kim and Shin, {Seung Yong} and Kang, {Jun Hyuk} and Hwan-Seok Yong and Na, {Jin Oh} and Choi, {Cheol Ung} and Kim, {Seong Hwan} and Kim, {Eung Ju} and Seung-Woon Rha and Park, {Chang Gyu} and Seo, {Hong Seog} and Oh, {Dong Joo} and Chun Hwang and Kim, {Young Hoon} and Lim, {Hong Euy}",
year = "2017",
month = "8",
day = "1",
doi = "10.1161/JAHA.117.006077",
language = "English",
volume = "6",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Influence of sex on the association between epicardial adipose tissue and left atrial transport function in patients with atrial fibrillation

T2 - A multislice computed tomography study

AU - Kim, Jin-Seok

AU - Shin, Seung Yong

AU - Kang, Jun Hyuk

AU - Yong, Hwan-Seok

AU - Na, Jin Oh

AU - Choi, Cheol Ung

AU - Kim, Seong Hwan

AU - Kim, Eung Ju

AU - Rha, Seung-Woon

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

AU - Hwang, Chun

AU - Kim, Young Hoon

AU - Lim, Hong Euy

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background--Epicardial adipose tissue (EAT) is known to play an important role in atrial fibrillation substrate remodeling; however, the influence of sex on the association between EAT and left atrial (LA) transport function has not been elucidated. Methods and Results--Of the 514 patients who underwent an index atrial fibrillation ablation procedure, 123 postmenopausal women with no history of hormone replacement therapy and 123 men who were matched for age, body mass index, type of atrial fibrillation, and CHADS2 score were enrolled. Before the procedure, LA volume, LA emptying fraction, and EAT volume were assessed using multislice computed tomography. Blood samples were obtained from a coronary sinus for analysis of serum adiponectin level before the ablation procedure. There were no differences in baseline demographics and laboratory findings between sexes. Compared with men, women had significantly less total EAT (P < 0.001) and higher serum adiponectin levels (P=0.022) but higher proportions of periatrial EAT to total EAT volume (P/T EAT ratio, P < 0.001), lower LA emptying fraction (P=0.042), and lower LA voltage (P=0.034). The ratio of periatrial to total EAT volume correlated significantly with LA emptying fraction and LA voltage in both sexes, whereas total EAT volume and serum adiponectin level did not. On multivariate analysis, increased LA volume and higher periatrial:total EAT volume ratio were independent predictors of decreased LA emptying fraction in both sexes. Conclusions--Compared with matched men, postmenopausal women with atrial fibrillation had higher periatrial adiposity, which was independently correlated with decreased LA voltage and LA transport function.

AB - Background--Epicardial adipose tissue (EAT) is known to play an important role in atrial fibrillation substrate remodeling; however, the influence of sex on the association between EAT and left atrial (LA) transport function has not been elucidated. Methods and Results--Of the 514 patients who underwent an index atrial fibrillation ablation procedure, 123 postmenopausal women with no history of hormone replacement therapy and 123 men who were matched for age, body mass index, type of atrial fibrillation, and CHADS2 score were enrolled. Before the procedure, LA volume, LA emptying fraction, and EAT volume were assessed using multislice computed tomography. Blood samples were obtained from a coronary sinus for analysis of serum adiponectin level before the ablation procedure. There were no differences in baseline demographics and laboratory findings between sexes. Compared with men, women had significantly less total EAT (P < 0.001) and higher serum adiponectin levels (P=0.022) but higher proportions of periatrial EAT to total EAT volume (P/T EAT ratio, P < 0.001), lower LA emptying fraction (P=0.042), and lower LA voltage (P=0.034). The ratio of periatrial to total EAT volume correlated significantly with LA emptying fraction and LA voltage in both sexes, whereas total EAT volume and serum adiponectin level did not. On multivariate analysis, increased LA volume and higher periatrial:total EAT volume ratio were independent predictors of decreased LA emptying fraction in both sexes. Conclusions--Compared with matched men, postmenopausal women with atrial fibrillation had higher periatrial adiposity, which was independently correlated with decreased LA voltage and LA transport function.

KW - Atrial fibrillation

KW - Computed tomography

KW - Epicardial fat

KW - Left atrial function

KW - Sex differences

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U2 - 10.1161/JAHA.117.006077

DO - 10.1161/JAHA.117.006077

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VL - 6

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

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