Influence of socioeconomic status on survival and clinical outcomes in patients with advanced gastric cancer after chemotherapy

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2 Citations (Scopus)

Abstract

Background: Socioeconomic inequalities are known to influence the survival of cancer patients due to differences in treatment modalities and disease extent at diagnosis. However, there are few studies regarding the influence of socioeconomic status on patient survival, especially after palliative chemotherapy for advanced gastric cancer. Patients and Methods: This retrospective study was performed on 138 advanced gastric cancer patients who received palliative chemotherapy. Demographic, socioeconomic, and cancer-related variables were analyzed according to education level. Effects of socioeconomic factors and cancer-related variables on patient survival were also evaluated. Results: In our study, higher education level (> 6 years of schooling; p = 0.01), disease control (p < 0.01), and a greater number of chemotherapeutic agents (≥ 5 drugs; p < 0.01) were associated with a significant increase in median survival. Multivariate analysis showed that a higher education level (hazard ratio (HR) 0.53; 95% confidence interval (CI) 0.35-0.82; p < 0.01), disease control (HR 0.21; 95% CI 0.13-0.34), and total number of chemotherapeutic agents used (HR 0.44; 95% CI 0.26-0.73) were significantly associated with prolonged survival. Conclusions: Among socioeconomic factors, only higher education level was associated with better survival. Increase in survival was also associated with clinical outcomes, including total number of chemotherapeutic agents used and disease control after chemotherapy.

Original languageEnglish
Pages (from-to)310-314
Number of pages5
JournalOncology Research and Treatment
Volume37
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Social Class
Stomach Neoplasms
Drug Therapy
Survival
Education
Confidence Intervals
Safety Management
Neoplasms
Multivariate Analysis
Retrospective Studies
Demography
Pharmaceutical Preparations

Keywords

  • Advanced gastric cancer
  • Chemotherapy
  • Socioeconomic status
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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title = "Influence of socioeconomic status on survival and clinical outcomes in patients with advanced gastric cancer after chemotherapy",
abstract = "Background: Socioeconomic inequalities are known to influence the survival of cancer patients due to differences in treatment modalities and disease extent at diagnosis. However, there are few studies regarding the influence of socioeconomic status on patient survival, especially after palliative chemotherapy for advanced gastric cancer. Patients and Methods: This retrospective study was performed on 138 advanced gastric cancer patients who received palliative chemotherapy. Demographic, socioeconomic, and cancer-related variables were analyzed according to education level. Effects of socioeconomic factors and cancer-related variables on patient survival were also evaluated. Results: In our study, higher education level (> 6 years of schooling; p = 0.01), disease control (p < 0.01), and a greater number of chemotherapeutic agents (≥ 5 drugs; p < 0.01) were associated with a significant increase in median survival. Multivariate analysis showed that a higher education level (hazard ratio (HR) 0.53; 95{\%} confidence interval (CI) 0.35-0.82; p < 0.01), disease control (HR 0.21; 95{\%} CI 0.13-0.34), and total number of chemotherapeutic agents used (HR 0.44; 95{\%} CI 0.26-0.73) were significantly associated with prolonged survival. Conclusions: Among socioeconomic factors, only higher education level was associated with better survival. Increase in survival was also associated with clinical outcomes, including total number of chemotherapeutic agents used and disease control after chemotherapy.",
keywords = "Advanced gastric cancer, Chemotherapy, Socioeconomic status, Survival",
author = "Choi, {In Keun} and Hyun, {Jong Jin} and Kim, {Seung Young} and Jung, {Sung Woo} and Koo, {Ja Seol} and Kim, {Jong Han} and Yim, {Hyung Joon} and Lee, {Sang Woo}",
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language = "English",
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pages = "310--314",
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TY - JOUR

T1 - Influence of socioeconomic status on survival and clinical outcomes in patients with advanced gastric cancer after chemotherapy

AU - Choi, In Keun

AU - Hyun, Jong Jin

AU - Kim, Seung Young

AU - Jung, Sung Woo

AU - Koo, Ja Seol

AU - Kim, Jong Han

AU - Yim, Hyung Joon

AU - Lee, Sang Woo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Socioeconomic inequalities are known to influence the survival of cancer patients due to differences in treatment modalities and disease extent at diagnosis. However, there are few studies regarding the influence of socioeconomic status on patient survival, especially after palliative chemotherapy for advanced gastric cancer. Patients and Methods: This retrospective study was performed on 138 advanced gastric cancer patients who received palliative chemotherapy. Demographic, socioeconomic, and cancer-related variables were analyzed according to education level. Effects of socioeconomic factors and cancer-related variables on patient survival were also evaluated. Results: In our study, higher education level (> 6 years of schooling; p = 0.01), disease control (p < 0.01), and a greater number of chemotherapeutic agents (≥ 5 drugs; p < 0.01) were associated with a significant increase in median survival. Multivariate analysis showed that a higher education level (hazard ratio (HR) 0.53; 95% confidence interval (CI) 0.35-0.82; p < 0.01), disease control (HR 0.21; 95% CI 0.13-0.34), and total number of chemotherapeutic agents used (HR 0.44; 95% CI 0.26-0.73) were significantly associated with prolonged survival. Conclusions: Among socioeconomic factors, only higher education level was associated with better survival. Increase in survival was also associated with clinical outcomes, including total number of chemotherapeutic agents used and disease control after chemotherapy.

AB - Background: Socioeconomic inequalities are known to influence the survival of cancer patients due to differences in treatment modalities and disease extent at diagnosis. However, there are few studies regarding the influence of socioeconomic status on patient survival, especially after palliative chemotherapy for advanced gastric cancer. Patients and Methods: This retrospective study was performed on 138 advanced gastric cancer patients who received palliative chemotherapy. Demographic, socioeconomic, and cancer-related variables were analyzed according to education level. Effects of socioeconomic factors and cancer-related variables on patient survival were also evaluated. Results: In our study, higher education level (> 6 years of schooling; p = 0.01), disease control (p < 0.01), and a greater number of chemotherapeutic agents (≥ 5 drugs; p < 0.01) were associated with a significant increase in median survival. Multivariate analysis showed that a higher education level (hazard ratio (HR) 0.53; 95% confidence interval (CI) 0.35-0.82; p < 0.01), disease control (HR 0.21; 95% CI 0.13-0.34), and total number of chemotherapeutic agents used (HR 0.44; 95% CI 0.26-0.73) were significantly associated with prolonged survival. Conclusions: Among socioeconomic factors, only higher education level was associated with better survival. Increase in survival was also associated with clinical outcomes, including total number of chemotherapeutic agents used and disease control after chemotherapy.

KW - Advanced gastric cancer

KW - Chemotherapy

KW - Socioeconomic status

KW - Survival

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