Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder

Heon-Jeong Lee, Min-Soo Lee, Rhee Hun Kang, Hyun Kim, Soonduck Kim, Baik Seok Kee, Young Hoon Kim, Yong Ku Kim, Jung Bum Kim, Byung Kil Yeon, Kang Seob Oh, Byung Hoon Oh, Jin Sang Yoon, Chul Lee, Han Yong Jung, Ik Seung Chee, In Ho Paik

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188 Citations (Scopus)

Abstract

Posttraumatic stress disorder (PTSD) is a prevalent anxiety disorder marked by behavioral, physiologic, and hormonal alterations. The etiology of PTSD is unknown, although exposure to a traumatic event constitutes a necessary, but not sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. The present study examined the possible association between the serotonin- transporter-linked polymorphic region (SERTPR) and PTSD. The genotype and allele frequencies of the SERTPR were analyzed in 100 PTSD patients and 197 unrelated healthy controls using a case-control design. The frequency of the s/s genotype was significantly higher in PTSD patients than in normal controls. These findings suggest that the SERTPR s/s genotype is one of the genetic factors for the susceptibility to PTSD. Further investigations are required into the influence of gene polymorphisms on the biological mechanisms of PTSD, its clinical expression, and its response to treatment.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalDepression and Anxiety
Volume21
Issue number3
DOIs
Publication statusPublished - 2005 Aug 4

Keywords

  • Polymorphism
  • PTSD
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

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    Lee, H-J., Lee, M-S., Kang, R. H., Kim, H., Kim, S., Kee, B. S., Kim, Y. H., Kim, Y. K., Kim, J. B., Yeon, B. K., Oh, K. S., Oh, B. H., Yoon, J. S., Lee, C., Jung, H. Y., Chee, I. S., & Paik, I. H. (2005). Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depression and Anxiety, 21(3), 135-139. https://doi.org/10.1002/da.20064