Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia

Alessandro Serretti, Alberto Chiesa, Stefano Porcelli, Changsu Han, Ashwin A. Patkar, Soo Jung Lee, Moon Ho Park, Chi Un Pae

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The present study is aimed at exploring whether some single nucleotide polymorphisms (SNPs) within the tryptophan hydroxylase 2 gene (TPH2) could be associated with major depression (MD), bipolar disorder (BD) and schizophrenia and whether they could predict clinical outcomes in Korean in-patients treated with antidepressants, mood stabilizers and antipsychotics, respectively. One hundred forty-five patients with MD, 132 patients with BD, 221 patients with schizophrenia and 170 psychiatrically healthy controls were genotyped for six TPH2 SNPs (rs4570625, rs10748185, rs11179027, rs1386498, rs4469933, and rs17110747). Baseline and final clinical measures, including the Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale and Positive and Negative Syndrome Scale, for patients with MD, BD and schizophrenia, respectively were recorded. None of the SNPs under investigation were associated with MD, BD and schizophrenia. However, in patients with MD, the rs4570625-rs10748185 G-A haplotype was significantly associated with higher endpoint MADRS severity, though not with response. Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments.

Original languageEnglish
Pages (from-to)26-32
Number of pages7
JournalPsychiatry Research
Volume189
Issue number1
DOIs
Publication statusPublished - 2011 Aug 30

Keywords

  • Bipolar disorder
  • Major depression
  • Schizophrenia
  • Tryptophan hydroxylase 2

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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