Inhibition of brain tumor cell proliferation by alternating electric fields

Hyesun Jeong, Jiwon Sung, Seung Ick Oh, Seonghoon Jeong, Eui Kwan Koh, Sunghoi Hong, Myonggeun Yoon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study was designed to investigate the mechanism by which electric fields affect cell function, and to determine the optimal conditions for electric field inhibition of cancer cell proliferation. Low-intensity (<2 V/cm) and intermediate-frequency (100-300 kHz) alternating electric fields were applied to glioblastoma cell lines. These electric fields inhibited cell proliferation by inducing cell cycle arrest and abnormal mitosis due to the malformation of microtubules. These effects were significantly dependent on the intensity and frequency of applied electric fields.

Original languageEnglish
Article number203703
JournalApplied Physics Letters
Volume105
Issue number20
DOIs
Publication statusPublished - 2014 Nov 17

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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