Inhibition of interleukin-12 production in lipopolysaccharide- activated mouse macrophages by hpyericin, an active component of Hypericin perforatum

B. Y. Kang, S. W. Chung, T. S. Kim

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Hypericin, an active component of Hypericum perforatum, was evaluated for the regulation of interleukin-12 (IL-12) production in mouse macrophages. Hypericin significantly inhibited IL-12 production in lipopolysaccharide-activated macrophages in a dose-dependent manner (IC50 = 1.45 μg/ml). Furthermore, hypericin potently inhibited the activation of IL-12 gene promoter, suggesting that hypericin negatively regulated IL-12 production at the transcription level. These results may explain some known biological activities of hypericin including its anti-rheumatic effect.

Original languageEnglish
Pages (from-to)364-366
Number of pages3
JournalPlanta Medica
Volume67
Issue number4
DOIs
Publication statusPublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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