Inhibition of interleukin-12 production in lipopolysaccharide- activated mouse macrophages by hpyericin, an active component of Hypericin perforatum

B. Y. Kang, S. W. Chung, Tae Sung Kim

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Hypericin, an active component of Hypericum perforatum, was evaluated for the regulation of interleukin-12 (IL-12) production in mouse macrophages. Hypericin significantly inhibited IL-12 production in lipopolysaccharide-activated macrophages in a dose-dependent manner (IC 50 = 1.45 μg/ml). Furthermore, hypericin potently inhibited the activation of IL-12 gene promoter, suggesting that hypericin negatively regulated IL-12 production at the transcription level. These results may explain some known biological activities of hypericin including its anti-rheumatic effect.

Original languageEnglish
Pages (from-to)364-366
Number of pages3
JournalPlanta Medica
Issue number4
Publication statusPublished - 2001 Jul 9
Externally publishedYes


ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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