Inhibition of interleukin-12 production in mouse macrophages via suppression of nuclear factor-κB binding activity by Phyllostachys nigra var. henonis

Seung Hyun Kim, Tae Sung Kim, Sung Jun Kim, Chi Nam Seong, Oh Hyung Lee, Hyo Jung Lee, Jin Cheol Yoo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Pharmacological inhibition of interleukin-12 (IL-12) production may be a therapeutic strategy for preventing development and progression of disease in experimental models of autoimmunity. The acetone fraction prepared from bamboo, Phyllostachys nigra var. henonis, potently inhibited the Lipo polysaccharide (LPS)-induced IL-12 production from RAW264.7 monocytic cell-line in a dose-dependent manner. The repressive effect mapped to a region in the IL-12 gene promoter containing a binding site for NF-κB. Furthermore, activation of macrophages by LPS resulted in markedly enhanced binding activity to the NF-κB site, which significantly decreased upon addition of the acetone fraction of Phyllostachys nigra var. henonis. This indicated that the acetone fraction inhibited IL-12 production in LPS-activated macrophages via inhibition of NF-κB binding activity.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalImmunopharmacology and Immunotoxicology
Volume29
Issue number1
DOIs
Publication statusPublished - 2007 Jan

Keywords

  • Bamboo Leaf
  • Interleukin-12 Production
  • Macrophage
  • Nuclear Factor-κB
  • Phyllostachys Nigra var. Henonis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

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