Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng

Ji Hye Lee, Jin Sun Shim, Mi Sook Chung, Seung Taik Lim, Kyung Hyun Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number1
DOIs
Publication statusPublished - 2009 Feb 2

Fingerprint

Panax
Pathogens
Adhesives
Polysaccharides
Adhesion
Bacteria
Hydrolysis
Enzymatic hydrolysis
Oligosaccharides
Skin
Cells
Cell Line

Keywords

  • Anti-adhesion
  • Panax ginseng
  • Pathogenic bacteria
  • Polysaccharide

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng. / Lee, Ji Hye; Shim, Jin Sun; Chung, Mi Sook; Lim, Seung Taik; Kim, Kyung Hyun.

In: Bioscience, Biotechnology and Biochemistry, Vol. 73, No. 1, 02.02.2009, p. 209-212.

Research output: Contribution to journalArticle

Lee, Ji Hye ; Shim, Jin Sun ; Chung, Mi Sook ; Lim, Seung Taik ; Kim, Kyung Hyun. / Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng. In: Bioscience, Biotechnology and Biochemistry. 2009 ; Vol. 73, No. 1. pp. 209-212.
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