Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng

Ji Hye Lee, Jin Sun Shim, Mi Sook Chung, Seung Taik Lim, Kyung Hyun Kim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number1
DOIs
Publication statusPublished - 2009 Feb 2

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Keywords

  • Anti-adhesion
  • Panax ginseng
  • Pathogenic bacteria
  • Polysaccharide

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

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