Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

Hyuncheol Oh; Beom Seok Kim; Eun Young Bae; Min Soo Kim; Bo Yeon Kim; Hyang Burm Lee; Chang Jin Kim; Jong Seog Ahn

doi:10.7164/antibiotics.57.528

Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

Hyuncheol Oh, Beom Seok Kim, Eun Young Bae, Min Soo Kim, Bo Yeon Kim, Hyang Burm Lee, Chang Jin Kim, Jong Seog Ahn

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, ⁹⁾ and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.

Original language	English
Pages (from-to)	528-531
Number of pages	4
Journal	Journal of Antibiotics
Volume	57
Issue number	8
DOIs	https://doi.org/10.7164/antibiotics.57.528
Publication status	Published - 2004 Aug
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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title = "Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232",

abstract = "In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, 9) and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.",

author = "Hyuncheol Oh and Kim, {Beom Seok} and Bae, {Eun Young} and Kim, {Min Soo} and Kim, {Bo Yeon} and Lee, {Hyang Burm} and Kim, {Chang Jin} and Ahn, {Jong Seog}",

year = "2004",

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doi = "10.7164/antibiotics.57.528",

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AU - Oh, Hyuncheol

AU - Kim, Beom Seok

AU - Bae, Eun Young

AU - Kim, Min Soo

AU - Kim, Bo Yeon

AU - Lee, Hyang Burm

AU - Kim, Chang Jin

AU - Ahn, Jong Seog

PY - 2004/8

Y1 - 2004/8

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AB - In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, 9) and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.

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Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

Abstract

ASJC Scopus subject areas

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