Inhibition of PTP1B by metabolites from Micromucor ramannianus var. angulisporus CRM000232

Hyuncheol Oh, Beom Seok Kim, Eun Young Bae, Min Soo Kim, Bo Yeon Kim, Hyang Burm Lee, Chang Jin Kim, Jong Seog Ahn

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In summary, dimeric depside-type fungal matabolite 1, along with biogenetically related compounds 2 and 3, was isolated as a PTP1B inhibitor by bioassay guided fractionation from the EtOAc extract of M. ramannianus var. angulisporus. To our best knowledge, compound 1 is the first PTP1B inhibitor reported from fungal sources, 9) and it could serve as a lead compound in design and development of potent PTP-1B inhibitor.

Original languageEnglish
Pages (from-to)528-531
Number of pages4
JournalJournal of Antibiotics
Volume57
Issue number8
DOIs
Publication statusPublished - 2004 Aug

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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