Inhibitors of nitric oxide production from Artemisia princeps

Dayu Li, Xiang Hua Han, Seong Su Hong, Chul Lee, Moon Soon Lee, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-3 inhibited nitric oxide production with IC50 values of 19.5, 20.4 and 25.1 μM, respectively.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalNatural Product Sciences
Volume16
Issue number3
Publication statusPublished - 2010 Sep 1

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Keywords

  • Artemisia princeps
  • Compositae
  • Nitric oxide production inhibitor
  • Sesquiterpene lactone

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry

Cite this

Li, D., Han, X. H., Hong, S. S., Lee, C., Lee, M. S., Lee, D., Lee, M. K., & Hwang, B. Y. (2010). Inhibitors of nitric oxide production from Artemisia princeps. Natural Product Sciences, 16(3), 143-147.