Inhibitors of nitric oxide production from Artemisia princeps

Dayu Li; Xiang Hua Han; Seong Su Hong; Chul Lee; Moon Soon Lee; Dongho Lee; Mi Kyeong Lee; Bang Yeon Hwang

Inhibitors of nitric oxide production from Artemisia princeps

Dayu Li, Xiang Hua Han, Seong Su Hong, Chul Lee, Moon Soon Lee, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-3 inhibited nitric oxide production with IC₅₀ values of 19.5, 20.4 and 25.1 μM, respectively.

Original language	English
Pages (from-to)	143-147
Number of pages	5
Journal	Natural Product Sciences
Volume	16
Issue number	3
Publication status	Published - 2010 Sept

Keywords

Artemisia princeps
Compositae
Nitric oxide production inhibitor
Sesquiterpene lactone

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry

Cite this

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abstract = "The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-3 inhibited nitric oxide production with IC50 values of 19.5, 20.4 and 25.1 μM, respectively.",

keywords = "Artemisia princeps, Compositae, Nitric oxide production inhibitor, Sesquiterpene lactone",

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AU - Li, Dayu

AU - Han, Xiang Hua

AU - Hong, Seong Su

AU - Lee, Chul

AU - Lee, Moon Soon

AU - Lee, Dongho

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

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AB - The chromatographic separation of a methanol extract of Artemisia princes led to the isolation of two sesquiterpene lactones, artecanin (1) and canin (2), together with a flavonoid, eupatilin (3). Their structures were determined by 1D, 2D-NMR and MS data analysis. All of the isolates were evaluated for their potential to inhibit the LPS-induced production of nitric oxide in murine macrophage RAW 264.7 cells. Compounds 1-3 inhibited nitric oxide production with IC50 values of 19.5, 20.4 and 25.1 μM, respectively.

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KW - Compositae

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KW - Sesquiterpene lactone

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Inhibitors of nitric oxide production from Artemisia princeps

Abstract

Keywords

ASJC Scopus subject areas

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