Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells

Jin Park, Qian Li, Young Tae Chang, Tae Sung Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4+ T cells, is an important stimulus for the switch of the antibody isotype to IgE in both mice and humans. In this study we investigated the inhibitory activity of IL-4 production in activated T cells by screening ceramide derivatives prepared by solid phase combinatorial chemistry. Many ceramide derivatives significantly inhibited IL-4 production in T cells. In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents.

Original languageEnglish
Pages (from-to)2589-2595
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume13
Issue number7
DOIs
Publication statusPublished - 2005 Apr 1
Externally publishedYes

Fingerprint

T-cells
Ceramides
Interleukin-4
T-Lymphocytes
Derivatives
Immunoglobulin E
Anti-Allergic Agents
Viral Tumor Antigens
Allergens
Screening
Hypersensitivity
Acetates
Switches
Antigens
Antibodies

Keywords

  • Allergy
  • Ceramide library
  • Interleukin-4
  • T cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells. / Park, Jin; Li, Qian; Chang, Young Tae; Kim, Tae Sung.

In: Bioorganic and Medicinal Chemistry, Vol. 13, No. 7, 01.04.2005, p. 2589-2595.

Research output: Contribution to journalArticle

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