Inhibitory activity of a ceramide library on interleukin-4 production from activated T cells

Jin Park, Qian Li, Young Tae Chang, Tae Sung Kim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Allergic diseases are hypersensitivity disorders associated with the production of specific immunoglobulin E (IgE) to environmental allergens. Interleukin (IL)-4, produced primarily by CD4+ T cells, is an important stimulus for the switch of the antibody isotype to IgE in both mice and humans. In this study we investigated the inhibitory activity of IL-4 production in activated T cells by screening ceramide derivatives prepared by solid phase combinatorial chemistry. Many ceramide derivatives significantly inhibited IL-4 production in T cells. In particular, ceramide derivatives with a lauroyl group showed strong inhibitory activities on IL-4 production in both phorbol 12-myristate 13-acetate (PMA)-activated EL4 T cells and antigen-primed cells, suggesting that they can be used as compounds for the development of anti-allergic agents.

Original languageEnglish
Pages (from-to)2589-2595
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume13
Issue number7
DOIs
Publication statusPublished - 2005 Apr 1
Externally publishedYes

Keywords

  • Allergy
  • Ceramide library
  • Interleukin-4
  • T cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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