Abstract
The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC 50 values of 4.6-21.6 μM.
| Original language | English |
|---|---|
| Pages (from-to) | 706-708 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 22 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 Jan 1 |
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Keywords
- Nardostachys chinensis
- Nitric oxide inhibitor
- Sesquiterpenoid
- Valerianaceae
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry
- Biochemistry
Cite this
Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages. / Hwang, Ji Sang; Lee, Seon A.; Hong, Seong Su; Han, Xiang Hua; Lee, Chul; Lee, Dongho; Lee, Chong Kil; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 1, 01.01.2012, p. 706-708.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages
AU - Hwang, Ji Sang
AU - Lee, Seon A.
AU - Hong, Seong Su
AU - Han, Xiang Hua
AU - Lee, Chul
AU - Lee, Dongho
AU - Lee, Chong Kil
AU - Hong, Jin Tae
AU - Kim, Youngsoo
AU - Lee, Mi Kyeong
AU - Hwang, Bang Yeon
PY - 2012/1/1
Y1 - 2012/1/1
N2 - The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC 50 values of 4.6-21.6 μM.
AB - The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC 50 values of 4.6-21.6 μM.
KW - Nardostachys chinensis
KW - Nitric oxide inhibitor
KW - Sesquiterpenoid
KW - Valerianaceae
UR - http://www.scopus.com/inward/record.url?scp=84655162129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84655162129&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2011.10.043
DO - 10.1016/j.bmcl.2011.10.043
M3 - Article
C2 - 22079762
AN - SCOPUS:84655162129
VL - 22
SP - 706
EP - 708
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 1
ER -