Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages

Ji Sang Hwang, Seon A. Lee, Seong Su Hong, Xiang Hua Han, Chul Lee, Dongho Lee, Chong Kil Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC 50 values of 4.6-21.6 μM.

Original languageEnglish
Pages (from-to)706-708
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1

Fingerprint

Nardostachys
Rhizome
Macrophages
Fractionation
Nitric Oxide
Alcohols
Nuclear magnetic resonance
4-coumaric acid
isoferulic acid
nardosinone
desoxonarchinol A
ursolic acid
pinoresinol

Keywords

  • Nardostachys chinensis
  • Nitric oxide inhibitor
  • Sesquiterpenoid
  • Valerianaceae

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages. / Hwang, Ji Sang; Lee, Seon A.; Hong, Seong Su; Han, Xiang Hua; Lee, Chul; Lee, Dongho; Lee, Chong Kil; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 1, 01.01.2012, p. 706-708.

Research output: Contribution to journalArticle

Hwang, JS, Lee, SA, Hong, SS, Han, XH, Lee, C, Lee, D, Lee, CK, Hong, JT, Kim, Y, Lee, MK & Hwang, BY 2012, 'Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages', Bioorganic and Medicinal Chemistry Letters, vol. 22, no. 1, pp. 706-708. https://doi.org/10.1016/j.bmcl.2011.10.043
Hwang, Ji Sang ; Lee, Seon A. ; Hong, Seong Su ; Han, Xiang Hua ; Lee, Chul ; Lee, Dongho ; Lee, Chong Kil ; Hong, Jin Tae ; Kim, Youngsoo ; Lee, Mi Kyeong ; Hwang, Bang Yeon. / Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages. In: Bioorganic and Medicinal Chemistry Letters. 2012 ; Vol. 22, No. 1. pp. 706-708.
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