TY - JOUR
T1 - Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages
AU - Hwang, Ji Sang
AU - Lee, Seon A.
AU - Hong, Seong Su
AU - Han, Xiang Hua
AU - Lee, Chul
AU - Lee, Dongho
AU - Lee, Chong Kil
AU - Hong, Jin Tae
AU - Kim, Youngsoo
AU - Lee, Mi Kyeong
AU - Hwang, Bang Yeon
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MRC, 2010-0029480 ) and a grant from the Korean Ministry of Education, Science and Technology (The Regional Core Research Program/Chungbuk BIT Research-Oriented University Consortium).
PY - 2012/1/1
Y1 - 2012/1/1
N2 - The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC 50 values of 4.6-21.6 μM.
AB - The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC 50 values of 4.6-21.6 μM.
KW - Nardostachys chinensis
KW - Nitric oxide inhibitor
KW - Sesquiterpenoid
KW - Valerianaceae
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U2 - 10.1016/j.bmcl.2011.10.043
DO - 10.1016/j.bmcl.2011.10.043
M3 - Article
C2 - 22079762
AN - SCOPUS:84655162129
VL - 22
SP - 706
EP - 708
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 1
ER -