Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages

Jin Woo Lee, Ji Hoon Lee, Chul Lee, Qinghao Jin, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of the MeOH extract from the roots of Sophora tonkinensis resulted in the isolation of a new pterocarpan glycoside (1) together with nine known compounds, maackiain (2), sophoranone (3), sophoranochromene (4), pinoresinol (5), syringaresinol (6), medioresinol (7), 4′,7-dihydroxyflavone (8), calycosin (9), and genistein (10). The structure of the new compound was determined on the basis of spectroscopic analysis including NMR and CD data in combination with acid hydrolysis. Compounds 1-4 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values ranging from 13.6 to 33.0 μM in RAW 264.7 macrophages.

Original languageEnglish
Pages (from-to)960-962
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume25
Issue number4
DOIs
Publication statusPublished - 2015 Feb 15

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Keywords

  • Leguminosae
  • Nitric oxide production inhibitor
  • Pterocarpan
  • Sophora tonkinensis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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