Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages

Chul Lee, Jin Woo Lee, Qinghao Jin, Dae Sik Jang, Sung Joon Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as 1D, 2D NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC 50 value of 18.1 μM.

Original languageEnglish
Pages (from-to)4263-4266
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number14
DOIs
Publication statusPublished - 2013 Jul 15

Keywords

  • (2S)-Pinocembrin
  • Dalbergia odorifera
  • Isoflavonoid
  • Leguminosae
  • Nitric oxide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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