Inhibitory effect of 2-arylbenzofurans from the Mori Cortex Radicis (moraceae) on oxygen glucose deprivation (OGD)-induced cell death of SH-SY5Y cells

Hak Ju Lee, Da Hyun Lyu, Uk Koo, Sung Jin Lee, Seong Su Hong, Kemok Kim, Kyeong Ho Kim, Dongho Lee, Woongchon Mar

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Three known 2-arylbenzofurans, moracin P (1), moracin O (2) and mulberrofuran Q (3) were isolated from the MeOH extract of the Mori Cortex Radicis. These compounds 1-3 enhanced cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells, which was measured by MTT reduction assay. (EC50 values of 10.4, 12.6, and 15.9 μM, respectively). In addition, the compounds 1-3 were examined for their inhibitory effect on OGD-induced ROS production by FACS analysis. We observed these compounds reduced ROS production in OGD-induced cell death (IC50 values of 1.9, 0.3 and 12.1 μM, respectively). Consequently, reactive oxygen species (ROS) were overexpressed in OGD-induced cells and all three compounds reduced ROS induced by OGD in dosedependent manner. Taken together, compounds 1-3 might protect neuronal cell death against the oxidative stress induced by OGD, though further studies in vitro and in vivo models are necessary.

Original languageEnglish
Pages (from-to)1373-1380
Number of pages8
JournalArchives of pharmacal research
Volume34
Issue number8
DOIs
Publication statusPublished - 2011 Aug

Keywords

  • 2-Arylbenzofurans
  • MTT
  • Moraceae
  • Mori Cortex Radicis
  • Oxygen-glucose deprivation
  • ROS

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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