Abstract
Objective: A number of case reports have been described regarding drug interactions with 5-fluorouracil (5-FU) and co-administered drugs. However, little is known regarding the inhibitory potential of 5-FU on the metabolism of co-administered drugs by cytochrome P450 (CYP). The aim of the present study was to elucidate the inhibitory effect of 5-FU on CYP isoforms using human liver microsomes. Methods: The inhibitory effect of 5-FU on CYP1A2, CYP2C9, CYP2C19, CYP2C8, CYP2E1, CYP2D6, and CYP3A4 activities was examined with specific probe drugs in human liver microsomes. Results: 5-FU showed little or no inhibitory effect on CYP-catalyzed reactions in human liver microsomal preparations. Conclusion: 5-FU has no inhibitory effect on CYP isoforms or drug metabolism causing drug interaction with 5-FU. The mechanism that causes drug interaction between co-administered drugs and 5-FU may not be related to direct CYP inhibition by 5-FU.
| Original language | English |
|---|---|
| Pages (from-to) | 407-409 |
| Number of pages | 3 |
| Journal | European Journal of Clinical Pharmacology |
| Volume | 59 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 2003 Sep 1 |
| Externally published | Yes |
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Keywords
- 5-Fluorouracil (5-FU)
- Cytochrome P
- Warfarin
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
Cite this
Inhibitory effect of 5-fluorouracil on human cytochrome P450 isoforms in human liver microsomes. / Park, Ji-Young; Kim, Kyoung Ah.
In: European Journal of Clinical Pharmacology, Vol. 59, No. 5-6, 01.09.2003, p. 407-409.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibitory effect of 5-fluorouracil on human cytochrome P450 isoforms in human liver microsomes
AU - Park, Ji-Young
AU - Kim, Kyoung Ah
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Objective: A number of case reports have been described regarding drug interactions with 5-fluorouracil (5-FU) and co-administered drugs. However, little is known regarding the inhibitory potential of 5-FU on the metabolism of co-administered drugs by cytochrome P450 (CYP). The aim of the present study was to elucidate the inhibitory effect of 5-FU on CYP isoforms using human liver microsomes. Methods: The inhibitory effect of 5-FU on CYP1A2, CYP2C9, CYP2C19, CYP2C8, CYP2E1, CYP2D6, and CYP3A4 activities was examined with specific probe drugs in human liver microsomes. Results: 5-FU showed little or no inhibitory effect on CYP-catalyzed reactions in human liver microsomal preparations. Conclusion: 5-FU has no inhibitory effect on CYP isoforms or drug metabolism causing drug interaction with 5-FU. The mechanism that causes drug interaction between co-administered drugs and 5-FU may not be related to direct CYP inhibition by 5-FU.
AB - Objective: A number of case reports have been described regarding drug interactions with 5-fluorouracil (5-FU) and co-administered drugs. However, little is known regarding the inhibitory potential of 5-FU on the metabolism of co-administered drugs by cytochrome P450 (CYP). The aim of the present study was to elucidate the inhibitory effect of 5-FU on CYP isoforms using human liver microsomes. Methods: The inhibitory effect of 5-FU on CYP1A2, CYP2C9, CYP2C19, CYP2C8, CYP2E1, CYP2D6, and CYP3A4 activities was examined with specific probe drugs in human liver microsomes. Results: 5-FU showed little or no inhibitory effect on CYP-catalyzed reactions in human liver microsomal preparations. Conclusion: 5-FU has no inhibitory effect on CYP isoforms or drug metabolism causing drug interaction with 5-FU. The mechanism that causes drug interaction between co-administered drugs and 5-FU may not be related to direct CYP inhibition by 5-FU.
KW - 5-Fluorouracil (5-FU)
KW - Cytochrome P
KW - Warfarin
UR - http://www.scopus.com/inward/record.url?scp=0141483127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141483127&partnerID=8YFLogxK
U2 - 10.1007/s00228-003-0641-z
DO - 10.1007/s00228-003-0641-z
M3 - Article
VL - 59
SP - 407
EP - 409
JO - European Journal of Clinical Pharmacology
JF - European Journal of Clinical Pharmacology
SN - 0031-6970
IS - 5-6
ER -