Abstract
Objective: A number of case reports have been described regarding drug interactions with 5-fluorouracil (5-FU) and co-administered drugs. However, little is known regarding the inhibitory potential of 5-FU on the metabolism of co-administered drugs by cytochrome P450 (CYP). The aim of the present study was to elucidate the inhibitory effect of 5-FU on CYP isoforms using human liver microsomes. Methods: The inhibitory effect of 5-FU on CYP1A2, CYP2C9, CYP2C19, CYP2C8, CYP2E1, CYP2D6, and CYP3A4 activities was examined with specific probe drugs in human liver microsomes. Results: 5-FU showed little or no inhibitory effect on CYP-catalyzed reactions in human liver microsomal preparations. Conclusion: 5-FU has no inhibitory effect on CYP isoforms or drug metabolism causing drug interaction with 5-FU. The mechanism that causes drug interaction between co-administered drugs and 5-FU may not be related to direct CYP inhibition by 5-FU.
Original language | English |
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Pages (from-to) | 407-409 |
Number of pages | 3 |
Journal | European Journal of Clinical Pharmacology |
Volume | 59 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - 2003 Sep 1 |
Externally published | Yes |
Keywords
- 5-Fluorouracil (5-FU)
- Cytochrome P
- Warfarin
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)