Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose

Young Jun Shim, Ho Kyung Doo, Se Young Ahn, Yong Suk Kim, Je Kyung Seong, In Sun Park, Bon Hong Min

    Research output: Contribution to journalArticlepeer-review

    203 Citations (Scopus)

    Abstract

    The present study examined the inhibitory effect of aqueous extract from the gall of Rhus chinensis (AEGRC) on alpha-glucosidase activity, an enzyme responsible for digestion of carbohydrate to monosaccharides in the process of intestinal absorption. AEGRC inhibited Bacillus alpha-glucosidase acitvity with an IC50 of 0.9μg/ml. Its inhibition on alpha-glucosidase was determined to be noncompetitive and reversible when the enzyme-substrate mixture was simultaneously treated with AEGRC as an inhibitor. In addition, when it was orally administered to rats with sucrose (2g/kg), AEGRC (250-1000mg/kg) significantly suppressed the increase of blood glucose levels after sucrose loading in a dose dependent manner. These results suggest that AEGRC might exert anti-diabetic effect by suppressing carbohydrate absorption from intestine, and thereby reducing the postprandial increase of blood glucose.

    Original languageEnglish
    Pages (from-to)283-287
    Number of pages5
    JournalJournal of Ethnopharmacology
    Volume85
    Issue number2-3
    DOIs
    Publication statusPublished - 2003 Apr

    Keywords

    • Alpha-glucosidase inhibitor
    • Gall of Rhus chinensis
    • Postprandial hypoglycemic effect

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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