Inhibitory effect of chaga mushroom extract on compound 48/80-induced anaphylactic shock and IgE production in mice

Taek Joon Yoon, Sue Jung Lee, Eun Young Kim, Eun Hee Cho, Tae Bong Kang, Kwang Won Yu, Hyung Joo Suh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chaga mushrooms (Inonotus obliquus) are hypothesised to exhibit general immune-potentiating, anti-inflammatory, and antitumor properties, but their anti-allergic activities are not fully understood. Therefore, this study investigated whether a chaga mushroom extract (C-HE) might have anti-allergic activity. This activity was assessed through the levels of the IgE Ab produced in response to an allergen (OVA). The administration of C-HE prophylactically inhibited the systemic anaphylactic shock induced by compound 48/80 in mice. The oral administration of C-HE significantly reduced the total IgE levels in mice and slightly affected the production of IgG1. Furthermore, spleen cell cultures harvested from OVA-sensitised mice that had received C-HE orally showed a significant increase in Th1-derived responses (IFN-γ production). Therefore, our results suggest that the chaga mushroom extract may be used as an anti-allergic functional food.

Original languageEnglish
Pages (from-to)666-670
Number of pages5
JournalInternational Immunopharmacology
Volume15
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

Keywords

  • Allergy
  • Anaphylaxis
  • IgE
  • Inonotus obliquus
  • Ovalbumin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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