Inhibitory effect of Trolox on the migration and invasion of human lung and cervical cancer cells

Ho Joong Sung, Yoonseo Kim, Hyereen Kang, Jae Woong Sull, Yoon Suk Kim, Sung Wuk Jang, Jesang Ko

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The antioxidant 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is implicated in migration and invasion of metastatic tumors. However, the molecular mechanism underlying the effect of Trolox on metastatic cancer cells is not known. We found that a non-cytotoxic dose of Trolox decreased phorbol 12-myristate 13-acetate (PMA)-induced invasion and migration of both A549 and HeLa cancer cells. We also found that Trolox suppressed both the expression and the proteolytic activity of matrix metalloproteinase-9 (MMP-9), and that the promoter activity of PMA-induced MMP-9 was inhibited by Trolox. Our results show that Trolox inhibits the transcriptional activity of MMP-9 by suppression of NF-κB transactivation. These results indicate that Trolox inhibits NF-κB-mediated MMP-9 expression, leading to the suppression of migration and invasion in lung and cervical cancer cells. Trolox is a potential agent for clinical use in preventing the invasion and metastasis of human malignant lung and cervical cancers.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalInternational journal of molecular medicine
Volume29
Issue number2
DOIs
Publication statusPublished - 2012 Feb

Keywords

  • Cell migration
  • Cervical cancer
  • Invasion
  • Lung cancer
  • Matrix metalloproteinase-9
  • Trolox

ASJC Scopus subject areas

  • Genetics

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