Inhibitory effect of yellow myrobalan (Terminalia chebula) extract on fibrosis induced by carbon tetrachloride in rat liver

Yun Chang Koo, Chung Oui Hong, Mi Hyun Nam, Ji Hoon Kim, Sung Yong Yang, Nam Hee Won, Tae Sun Park, Kwang Won Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Ethyl acetate layer of methanol extract (TCE) of yellow myrobalan (Terminalia chebula) contains 2.4% of chebulic acid, a standard compound in TCE, which have a strong anti-oxidative effect and was reported in our previous study. Thirty-one male SD rats were randomly divided into 5 groups (normal control, CCl4 control, TCE control, CCl4+high dose TCE, and low dose TCE). Liver fibrosis was induced by i.p. injection of CCl4 and TCE were orally administrated. TCE decreased the up-regulated malondealdehyde value and increased the down-regulated ratio of GSH/GSSG content and activities of GRd, GPx, and GST compared to the CCl4 control group. Decreased dysfunction and inflammatory reaction in liver was confirmed by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, relative liver weight and infiltration of neutrophils. Also, TCE inhibited phenotype change of hepatic stellate cells (HSC) by reducing α-smooth muscle actin (α-SMA) gene expression and protein production. Inhibition of collagen 1A1 gene expression and protein production were also confirmed. From these results, TCE may be a useful material for preventing liver fibrosis.

Original languageEnglish
Pages (from-to)871-880
Number of pages10
JournalFood Science and Biotechnology
Volume22
Issue number3
DOIs
Publication statusPublished - 2013 Jun 1

Fingerprint

Terminalia chebula
Terminalia
carbon tetrachloride
Carbon Tetrachloride
fibrosis
Liver Cirrhosis
liver cirrhosis
Fibrosis
Gene Expression
Hepatic Stellate Cells
Control Groups
liver
Glutathione Disulfide
Neutrophil Infiltration
Liver
rats
extracts
Aspartate Aminotransferases
Alanine Transaminase
Smooth Muscle

Keywords

  • carbon tetrachloride
  • chebulic acid
  • liver fibrosis
  • Terminalia chebula

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Inhibitory effect of yellow myrobalan (Terminalia chebula) extract on fibrosis induced by carbon tetrachloride in rat liver. / Koo, Yun Chang; Hong, Chung Oui; Nam, Mi Hyun; Kim, Ji Hoon; Yang, Sung Yong; Won, Nam Hee; Park, Tae Sun; Lee, Kwang Won.

In: Food Science and Biotechnology, Vol. 22, No. 3, 01.06.2013, p. 871-880.

Research output: Contribution to journalArticle

Koo, Yun Chang ; Hong, Chung Oui ; Nam, Mi Hyun ; Kim, Ji Hoon ; Yang, Sung Yong ; Won, Nam Hee ; Park, Tae Sun ; Lee, Kwang Won. / Inhibitory effect of yellow myrobalan (Terminalia chebula) extract on fibrosis induced by carbon tetrachloride in rat liver. In: Food Science and Biotechnology. 2013 ; Vol. 22, No. 3. pp. 871-880.
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