Inhibitory effect on NO production of phenolic compounds from Myristica fragrans

To Dao Cuong, Tran Manh Hung, Minkyun Na, Do Thi Ha, Jin Cheol Kim, Dongho Lee, Sungwoo Ryoo, Jeong Hyung Lee, Jae Sue Choi, Byung Sun Min

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Three new phenolics: ((7S)-8′-(benzo[3′,4′]dioxol- 1′-yl)-7-hydroxypropyl)benzene-2,4-diol (1), ((7S)-8′-(4′- hydroxy-3′-methoxyphenyl)-7-hydroxypropyl)benzene-2,4-diol (2) and ((8R,8′S)-7-(4-hydroxy-3-methoxyphenyl)-8′-methylbutan-8-yl) -3′-methoxybenzene-4′,5′-diol (3), along with four known compounds (4-7) were isolated from the seeds of Myristica fragrans. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.

Original languageEnglish
Pages (from-to)6884-6887
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number22
DOIs
Publication statusPublished - 2011 Nov 15

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Keywords

  • Anti-inflammatory activity
  • Myristica fragrans
  • Myristicaceae
  • Phenolic

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Cuong, T. D., Hung, T. M., Na, M., Ha, D. T., Kim, J. C., Lee, D., Ryoo, S., Lee, J. H., Choi, J. S., & Min, B. S. (2011). Inhibitory effect on NO production of phenolic compounds from Myristica fragrans. Bioorganic and Medicinal Chemistry Letters, 21(22), 6884-6887. https://doi.org/10.1016/j.bmcl.2011.09.021