Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction

Whasun Lim, Gwonhwa Song

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Delphinidin is a member of the anthocyanidin family and is a natural pigment in red cabbage, berries, sweet potatoes and grapes. It possesses nutraceutical proper-ties against various chronic diseases and types of cancer. However, little is known about its preventative effects on epithelial ovarian cancer, a disease that is associated with a low survival rate, a poor prognosis and a high rate of recur-rence. The results of the present study demonstrated that the proliferation of SKOV3 cells decreased in a dose-dependent manner in response to treatment with delphinidin, and the phosphorylation of carcinogenic protein kinases associated with the progression of epithelial ovarian cancer was affected by delphinidin treatment. The levels of phosphorylated protein kinase B (AKT), ribosomal protein S6 kinase β-1 (P70S6K), ribosomal protein S (S6), extracellular signal-regulated kinase (ERK)1/2 and p38 were suppressed by increasing concentra-tions of delphinidin. Furthermore, the combination of certain pharmacological inhibitors, including phosphoinositide 3-kinase (PI3K; LY294002), ERK1/2 (U0126) and delphinidin significantly reduced the proliferation of SKOV3 cells and the phosphorylation of each of those target proteins. In addition, delphinidin treatment exerted anti-proliferative effects on paclitaxel-resistant SKOV3 cells, compared with treatment with paclitaxel alone. These results indicate that delphinidin inhibits the proliferation of SKOV3 cells through inactivation of PI3K/AKT and ERK1/2 mitogen-activated protein kinase signaling cascades, and that this cell signaling pathway may be a pivotal therapeutic target for the prevention of epithelial ovarian cancer, including paclitaxel-resistant ovarian cancer.

Original languageEnglish
Pages (from-to)810-818
Number of pages9
JournalOncology Letters
Volume14
Issue number1
DOIs
Publication statusPublished - 2017

Fingerprint

delphinidin
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Phosphatidylinositol 3-Kinases
Ovarian Neoplasms
Signal Transduction
Paclitaxel
Cell Proliferation
Ribosomal Protein S6
Phosphorylation
Ribosomal Protein S6 Kinases
70-kDa Ribosomal Protein S6 Kinases
Ipomoea batatas
Proto-Oncogene Proteins c-akt
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
1-Phosphatidylinositol 4-Kinase
Anthocyanins
Brassica
Protein S
Vitis

Keywords

  • Cell proliferation
  • Chemotherapy
  • Delphinidin
  • Ovarian cancer
  • Signal transduction

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction. / Lim, Whasun; Song, Gwonhwa.

In: Oncology Letters, Vol. 14, No. 1, 2017, p. 810-818.

Research output: Contribution to journalArticle

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