TY - JOUR
T1 - Injectable polydimethylsiloxane microfiller coated with zwitterionic polymer for enhanced biocompatibility
AU - Lee, Joonbum
AU - Choi, Jung Woo
AU - Hong, Kwang Dae
AU - Seo, Ji Hun
N1 - Funding Information:
This study was supported by a grant from Korea University , Korea University College of Medicine , and Korea University Ansan Hospital . This research was also supported by ATC+ Program ( 20014029 ) funded by Korea Evaluation Institute of Industrial Technology .
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021
Y1 - 2021
N2 - Silicone-based fillers have been applied in several branches of medicine, such as soft tissue augmentation, because of their stability and durability. However, the inherently hydrophobic surfaces of silicone occasionally cause excessive deposition of the fibrous matrix in vivo, leading to severe fibrosis. In this study, we evaluated the use of a zwitterionic copolymer to offer a facile surface treatment method for silicone-based fillers and performed a preclinical trial of the formulation as-prepared. The copolymer has amphiphilic moieties, which act as macromolecular surfactants that can functionalize and stabilize the silicone particles during fabrication. The effectiveness and safety of the particle filler were evaluated histologically by scoring the peri-implant tissues into previously defined categories. Our results suggest that zwitterion-coated silicone fillers can inhibit protein adsorption, and thus, help attenuate foreign body reactions in a rat model. This demonstrates their potential for wide application in different fields within the discipline of medicine.
AB - Silicone-based fillers have been applied in several branches of medicine, such as soft tissue augmentation, because of their stability and durability. However, the inherently hydrophobic surfaces of silicone occasionally cause excessive deposition of the fibrous matrix in vivo, leading to severe fibrosis. In this study, we evaluated the use of a zwitterionic copolymer to offer a facile surface treatment method for silicone-based fillers and performed a preclinical trial of the formulation as-prepared. The copolymer has amphiphilic moieties, which act as macromolecular surfactants that can functionalize and stabilize the silicone particles during fabrication. The effectiveness and safety of the particle filler were evaluated histologically by scoring the peri-implant tissues into previously defined categories. Our results suggest that zwitterion-coated silicone fillers can inhibit protein adsorption, and thus, help attenuate foreign body reactions in a rat model. This demonstrates their potential for wide application in different fields within the discipline of medicine.
KW - Antifouling
KW - Biocompatibility
KW - Foreign body reaction
KW - Injectable filler
KW - Silicone
KW - Zwitterionic polymer
UR - http://www.scopus.com/inward/record.url?scp=85119929450&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2021.112223
DO - 10.1016/j.colsurfb.2021.112223
M3 - Article
AN - SCOPUS:85119929450
VL - 210
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
SN - 0927-7765
M1 - 112223
ER -