Innate and adaptive functions of the CD1 pathway of antigen presentation

Se Ho Park, Ya Hui Chiu, Jayanthi Jayawardena, Jessica Roark, Uma Kavita, Albert Bendelac

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22 Citations (Scopus)

Abstract

In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to αβ T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-γ. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalSeminars in Immunology
Volume10
Issue number5
DOIs
Publication statusPublished - 1998 Oct
Externally publishedYes

Keywords

  • CD1
  • Glycolipids
  • Innate immunity
  • Interleukin-4
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Park, S. H., Chiu, Y. H., Jayawardena, J., Roark, J., Kavita, U., & Bendelac, A. (1998). Innate and adaptive functions of the CD1 pathway of antigen presentation. Seminars in Immunology, 10(5), 391-398. https://doi.org/10.1006/smim.1998.0139