Innate and adaptive functions of the CD1 pathway of antigen presentation

Se-Ho Park, Ya Hui Chiu, Jayanthi Jayawardena, Jessica Roark, Uma Kavita, Albert Bendelac

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to αβ T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-γ. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.

Original languageEnglish
Pages (from-to)391-398
Number of pages8
JournalSeminars in Immunology
Volume10
Issue number5
DOIs
Publication statusPublished - 1998 Oct 1
Externally publishedYes

Fingerprint

CD1 Antigens
Antigen Presentation
T-Lymphocytes
Immune System
Glycolipids
Type 1 Diabetes Mellitus
Bacterial Infections
Innate Immunity
Interleukin-4
Autoimmune Diseases
Cytokines
Antigens
Neoplasms

Keywords

  • CD1
  • Glycolipids
  • Innate immunity
  • Interleukin-4
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Park, S-H., Chiu, Y. H., Jayawardena, J., Roark, J., Kavita, U., & Bendelac, A. (1998). Innate and adaptive functions of the CD1 pathway of antigen presentation. Seminars in Immunology, 10(5), 391-398. https://doi.org/10.1006/smim.1998.0139

Innate and adaptive functions of the CD1 pathway of antigen presentation. / Park, Se-Ho; Chiu, Ya Hui; Jayawardena, Jayanthi; Roark, Jessica; Kavita, Uma; Bendelac, Albert.

In: Seminars in Immunology, Vol. 10, No. 5, 01.10.1998, p. 391-398.

Research output: Contribution to journalArticle

Park, S-H, Chiu, YH, Jayawardena, J, Roark, J, Kavita, U & Bendelac, A 1998, 'Innate and adaptive functions of the CD1 pathway of antigen presentation', Seminars in Immunology, vol. 10, no. 5, pp. 391-398. https://doi.org/10.1006/smim.1998.0139
Park, Se-Ho ; Chiu, Ya Hui ; Jayawardena, Jayanthi ; Roark, Jessica ; Kavita, Uma ; Bendelac, Albert. / Innate and adaptive functions of the CD1 pathway of antigen presentation. In: Seminars in Immunology. 1998 ; Vol. 10, No. 5. pp. 391-398.
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