Innate immune stimulation of exo-polymers prepared from Cordyceps sinensis by submerged culture

Taek Joon Yoon, Kwang Won Yu, Kwang Soon Shin, Hyung Joo Suh

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

After we prepared exo-polymers (EPS) from Cordyceps sinensis by submerged culture, prophylactic intravenous administration (i.v.) of EPS significantly inhibited metastasis in experimental lung metastasis of colon 26-M3.1 carcinoma. Cytotoxicity against Yac-1 tumor cells of natural killer (NK) cell, which was prepared by i.v. of EPS (100 μg/mouse), significantly augmented 2 days after EPS treatment. When NK cells were depleted by rabbit anti-asialo GM1 serum, even the EPS group totally abolished the inhibitory effect on lung metastasis of colon 26-M3.1 cells. EPS can stimulate innate immune system to inhibit tumor metastasis, and its anti-tumor metastasis is associated with macrophage and NK cell activation.

Original languageEnglish
Pages (from-to)1087-1093
Number of pages7
JournalApplied Microbiology and Biotechnology
Volume80
Issue number6
DOIs
Publication statusPublished - 2008 Oct

Keywords

  • Cordyceps sinensis
  • Cytokine
  • Exo-polymer
  • Innate immunity
  • NK cell
  • Tumor metastasis

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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