Innate immunity and transplantation tolerance: The potential role of TLRs/NLRs in GVHD

Ok S. Shin, Jason B. Harris

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic cell transplantation (HCT) and this occurs as donor T lymphocytes, activated by recipient antigen presenting cells (APC), attack the host tissues or organs. This APC activation is a crucial initial step of influencing the outcome of GVHD and is mediated by innate immune signaling. Toll-like receptors (TLRs) and nucleotide binding oligomerization domain (NOD)-like receptors (NLRs) are important components of innate immunity; both families of receptors are known for sensing various microbial ligands or danger signals. Signaling through TLRs/NLRs regulate activities of APCs, through phagocytosis, cytokine and chemokine release, delivery of APCs from peripheral tissues to draining lymph nodes, and antigen presentation. Several TLRs/NLRs have been identified and their ligands and signaling pathways have been described. Recent findings suggest a significant association of TLR/NLR polymorphisms with the increased risk for severe GVHD. Therefore, these TLR/NLR pathways likely contributing to immune response for GVHD may serve as novel therapeutic targets to facilitate allograft tolerance. This review summarizes the role of TLRs/NLRs innate immune receptors and signaling in GVHD pathophysiology

Original languageEnglish
Pages (from-to)69-79
Number of pages11
JournalKorean Journal of Hematology
Volume46
Issue number2
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • GVHD
  • Innate immunity
  • NLR
  • TLR
  • Transplantation

ASJC Scopus subject areas

  • Hematology

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