Inorganic nanoparticles for image-guided therapy

Hong Yeol Yoon, Sangmin Jeon, Dong Gil You, Jae Hyung Park, Ick Chan Kwon, Heebeom Koo, Kwang Meyung Kim

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Recently, nanotechnology has provided significant advances in biomedical applications including diagnosis and therapy. In particular, nanoparticles have emerged as valuable outcomes of nanotechnology due to their unique physicochemical properties based on size, shape, and surface properties. Among them, a large amount of research has reported imaging and therapeutic applications using inorganic nanoparticles with special properties. Inorganic nanoparticles developed for imaging and therapy contain metal (Au), metal oxide (Fe3O4, WO3, WO2.9), semiconductor nanocrystal (quantum dots (QDs)), and lanthanide-doped upconversion nanoparticles (UCNPs). Based on their intrinsic properties, they can generate heat, reactive oxygen species (ROS), or energy transfer, so that they can be used for both imaging and therapy. In this review, we introduce biocompatible inorganic nanoparticles for image-guided thermal and photodynamic therapy, and discuss their promising results from in vitro and in vivo studies for biomedical applications.

Original languageEnglish
Pages (from-to)124-134
Number of pages11
JournalBioconjugate Chemistry
Volume28
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

    Fingerprint

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Cite this

Yoon, H. Y., Jeon, S., You, D. G., Park, J. H., Kwon, I. C., Koo, H., & Kim, K. M. (2017). Inorganic nanoparticles for image-guided therapy. Bioconjugate Chemistry, 28(1), 124-134. https://doi.org/10.1021/acs.bioconjchem.6b00512