Insight of key factors influencing tumor targeting characteristics of glycol chitosan-based nanoparticles and in vivo applications

Sung Eun Kim, Ick Chan Kwon, Hae Ryong Song, Kyeongsoon Park

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Nanoparticles that have been developed to effectively deliver therapeutic drugs and imaging agents to tumor regions could increase therapeutic efficacy while dramatically reducing potential side effects with the capability of diagnosing tumors. In this review article, we discuss the development and optimization processes of glycol chitosan-based polymeric nanoparticles to accomplish the tasks of therapeutic drugs and imaging agents for cancer treatment. To achieve effective tumor imaging and therapy, we optimized the physicochemical properties of nanoparticles and examined several key factors (i.e., molecular weight, stability in the blood, deformability, and rapid cellular uptake), which are important issues influencing the in vivo biodistribution and tumor targeting ability of nanoparticles. Furthermore, we showed their applications in various animal tumor imaging and therapy studies. This review article suggests that the optimization processes for developing novel nanoparticle systems are necessarily required to obtain the most effective therapeutic drugs and imaging agents through in vitro and in vivo studies.

Original languageEnglish
Pages (from-to)1109-1117
Number of pages9
JournalMacromolecular Research
Volume20
Issue number11
DOIs
Publication statusPublished - 2012 Nov

Keywords

  • Disease imaging
  • Drug delivery
  • Glycol chitosan-based nanoparticles
  • Near-infrared fluorescence
  • Therapy

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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