Insulin-like growth factors and blastocyst development

R. C M Simmen, Yong Ko, F. A. Simmen

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The interactions between the maternal uterus and the developing conceptus that underlie normal blastocyst development and successful progression of pregnancy are complex. Recent studies implicate peptide growth factors in the initiation, establishment and maintenance of pregnancy and in maternal-embryonic communication. The insulin-like family of growth factors appear to function as key mediators of the coordinate development of the uterus and conceptus during early pregnancy by virtue of their ability to influence directly or indirectly, the synthesis and secretion of uterine and conceptus secretory proteins. The autocrine and paracrine modes of action of the insulin-like growth factors (IGFs) are modulated within the uterine microenvironment by Type I IGF receptors and IGF binding proteins (IGFBPs), which are themselves subject to local control within the uterus and conceptus. An understanding of the mechanisms by which IGFs regulate and are regulated by, the expression of conceptus signals for maternal recognition of pregnancy may provide novel insights and practical applications towards increasing reproductive efficiency in large animals.

Original languageEnglish
Pages (from-to)163-175
Number of pages13
JournalTheriogenology
Volume39
Issue number1
Publication statusPublished - 1993 Jan 1
Externally publishedYes

Fingerprint

conceptus
somatomedins
Blastocyst
Somatomedins
blastocyst
Uterus
Mothers
Pregnancy
pregnancy
uterus
Pregnancy Maintenance
Insulin-Like Growth Factor Binding Proteins
IGF Type 1 Receptor
growth factors
Intercellular Signaling Peptides and Proteins
insulin-like growth factor binding proteins
reproductive efficiency
Peptides
animal communication
mechanism of action

Keywords

  • aromatase
  • blastocyst development
  • growth factors
  • IGF
  • pregnancy
  • uterus

ASJC Scopus subject areas

  • veterinary(all)
  • Animal Science and Zoology

Cite this

Simmen, R. C. M., Ko, Y., & Simmen, F. A. (1993). Insulin-like growth factors and blastocyst development. Theriogenology, 39(1), 163-175.

Insulin-like growth factors and blastocyst development. / Simmen, R. C M; Ko, Yong; Simmen, F. A.

In: Theriogenology, Vol. 39, No. 1, 01.01.1993, p. 163-175.

Research output: Contribution to journalArticle

Simmen, RCM, Ko, Y & Simmen, FA 1993, 'Insulin-like growth factors and blastocyst development', Theriogenology, vol. 39, no. 1, pp. 163-175.
Simmen RCM, Ko Y, Simmen FA. Insulin-like growth factors and blastocyst development. Theriogenology. 1993 Jan 1;39(1):163-175.
Simmen, R. C M ; Ko, Yong ; Simmen, F. A. / Insulin-like growth factors and blastocyst development. In: Theriogenology. 1993 ; Vol. 39, No. 1. pp. 163-175.
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