TY - JOUR
T1 - Insulin resistance is associated with hypertensive response to exercise in non-diabetic hypertensive patients
AU - Park, Sungha
AU - Shim, Jaemin
AU - Kim, Jin Bae
AU - Ko, Young Guk
AU - Choi, Donghoon
AU - Ha, Jong Won
AU - Rim, Se Joong
AU - Jang, Yangsoo
AU - Chung, Namsik
N1 - Funding Information:
This work was supported by a grant from the Ministry of Health and Welfare, the Republic of Korea (00-PJ6-PG5-23-0001).
PY - 2006/7
Y1 - 2006/7
N2 - Aim: Insulin resistance is associated with increased sympathetic activity and elevated angiotensin II which may contribute to the excessive increase in arterial blood pressure during exercise. In this study, we hypothesized that increased insulin resistance will be significantly associated with hypertensive response to exercise (HRE) in non-diabetic hypertensive patients. Method: Two hundred seventy-five hypertensive patients were included in this study. HOMA-IR index using serum fasting glucose and insulin was calculated for insulin resistance. There were 79 patients with hypertensive response (age 56.1 ± 9.4 years) and 196 patients without hypertensive response (age 53.9 ± 8.9 years). Results: Insulin resistance, assessed by HOMA index, was significantly higher in hypertensive response group as compared to control (HOMA = 2.60 ± 1.54 versus 1.76 ± 0.86, P < 0.001). HOMA was an independent predictor of HRE when controlled for age, sex, BMI and baseline SBP (odds ratio = 2.008, P < 0.001). Also, HOMA was significantly correlated with the magnitude of SBP elevation controlled for age, sex, BMI and baseline SBP as well (β = 0.293, P < 0.001). In conclusion, this study shows that insulin resistance is a significant determinant of hypertensive response to exercise. Further studies to determine the prognostic significance of this finding is warranted.
AB - Aim: Insulin resistance is associated with increased sympathetic activity and elevated angiotensin II which may contribute to the excessive increase in arterial blood pressure during exercise. In this study, we hypothesized that increased insulin resistance will be significantly associated with hypertensive response to exercise (HRE) in non-diabetic hypertensive patients. Method: Two hundred seventy-five hypertensive patients were included in this study. HOMA-IR index using serum fasting glucose and insulin was calculated for insulin resistance. There were 79 patients with hypertensive response (age 56.1 ± 9.4 years) and 196 patients without hypertensive response (age 53.9 ± 8.9 years). Results: Insulin resistance, assessed by HOMA index, was significantly higher in hypertensive response group as compared to control (HOMA = 2.60 ± 1.54 versus 1.76 ± 0.86, P < 0.001). HOMA was an independent predictor of HRE when controlled for age, sex, BMI and baseline SBP (odds ratio = 2.008, P < 0.001). Also, HOMA was significantly correlated with the magnitude of SBP elevation controlled for age, sex, BMI and baseline SBP as well (β = 0.293, P < 0.001). In conclusion, this study shows that insulin resistance is a significant determinant of hypertensive response to exercise. Further studies to determine the prognostic significance of this finding is warranted.
KW - Hypertension
KW - Hypertensive response to exercise
KW - Insulin resistance
UR - http://www.scopus.com/inward/record.url?scp=33646775334&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2005.11.008
DO - 10.1016/j.diabres.2005.11.008
M3 - Article
C2 - 16413944
AN - SCOPUS:33646775334
VL - 73
SP - 65
EP - 69
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -
