Intakes of vitamin A, C, and E, and -carotene are associated with risk of cervical cancer

A case-control study in Korea

Jeongseon Kim, Mi Kyung Kim, Jae Kwan Lee, Jae Hoon Kim, Sung Kyong Son, Eun Seop Song, Kwang Beom Lee, Jung Pil Lee, Jong Min Lee, Young Mi Yun

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Cervical cancer is one of the most common gynecological malignancies in Korea, although the incidence has been declining in recent years. This study explored whether antioxidant vitamin intakes influenced the risk of cervical cancer. The association between antioxidant vitamin intakes and cervical cancer risk was calculated for 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models. Cases reported statistically lower mean dietary intakes of vitamin A, β-carotene, and vitamin C than did controls. Total intakes of vitamins A and E, which included both dietary and supplement intake, were also lower in cases. Those patients in the highest quartiles of dietary vitamin A, β-carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, β-carotene, and vitamin C: odds ratio (OR) = 0.36 [95% confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI = 0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of vitamins A, C, and E were strongly inversely associated with cervical cancer risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53 (CI = 0.28-0.99), respectively. The findings support a role for increased antioxidant vitamin intake in decreasing the risk of cervical cancer. These associations need to be assessed in large prospective studies with long-term follow-up.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalNutrition and Cancer
Volume62
Issue number2
DOIs
Publication statusPublished - 2010 Feb 1

Fingerprint

Carotenoids
Korea
Vitamin A
Vitamin E
Uterine Cervical Neoplasms
Ascorbic Acid
Case-Control Studies
Odds Ratio
Confidence Intervals
Vitamins
Antioxidants
Logistic Models
Dietary Supplements
Prospective Studies
Incidence
Neoplasms

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Oncology
  • Nutrition and Dietetics
  • Cancer Research

Cite this

Intakes of vitamin A, C, and E, and -carotene are associated with risk of cervical cancer : A case-control study in Korea. / Kim, Jeongseon; Kim, Mi Kyung; Lee, Jae Kwan; Kim, Jae Hoon; Son, Sung Kyong; Song, Eun Seop; Lee, Kwang Beom; Lee, Jung Pil; Lee, Jong Min; Yun, Young Mi.

In: Nutrition and Cancer, Vol. 62, No. 2, 01.02.2010, p. 181-189.

Research output: Contribution to journalArticle

Kim, Jeongseon ; Kim, Mi Kyung ; Lee, Jae Kwan ; Kim, Jae Hoon ; Son, Sung Kyong ; Song, Eun Seop ; Lee, Kwang Beom ; Lee, Jung Pil ; Lee, Jong Min ; Yun, Young Mi. / Intakes of vitamin A, C, and E, and -carotene are associated with risk of cervical cancer : A case-control study in Korea. In: Nutrition and Cancer. 2010 ; Vol. 62, No. 2. pp. 181-189.
@article{09f39ef821254ed0b16db84ea61e3346,
title = "Intakes of vitamin A, C, and E, and -carotene are associated with risk of cervical cancer: A case-control study in Korea",
abstract = "Cervical cancer is one of the most common gynecological malignancies in Korea, although the incidence has been declining in recent years. This study explored whether antioxidant vitamin intakes influenced the risk of cervical cancer. The association between antioxidant vitamin intakes and cervical cancer risk was calculated for 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models. Cases reported statistically lower mean dietary intakes of vitamin A, β-carotene, and vitamin C than did controls. Total intakes of vitamins A and E, which included both dietary and supplement intake, were also lower in cases. Those patients in the highest quartiles of dietary vitamin A, β-carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, β-carotene, and vitamin C: odds ratio (OR) = 0.36 [95{\%} confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI = 0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of vitamins A, C, and E were strongly inversely associated with cervical cancer risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53 (CI = 0.28-0.99), respectively. The findings support a role for increased antioxidant vitamin intake in decreasing the risk of cervical cancer. These associations need to be assessed in large prospective studies with long-term follow-up.",
author = "Jeongseon Kim and Kim, {Mi Kyung} and Lee, {Jae Kwan} and Kim, {Jae Hoon} and Son, {Sung Kyong} and Song, {Eun Seop} and Lee, {Kwang Beom} and Lee, {Jung Pil} and Lee, {Jong Min} and Yun, {Young Mi}",
year = "2010",
month = "2",
day = "1",
doi = "10.1080/01635580903305326",
language = "English",
volume = "62",
pages = "181--189",
journal = "Nutrition and Cancer",
issn = "0163-5581",
publisher = "Routledge",
number = "2",

}

TY - JOUR

T1 - Intakes of vitamin A, C, and E, and -carotene are associated with risk of cervical cancer

T2 - A case-control study in Korea

AU - Kim, Jeongseon

AU - Kim, Mi Kyung

AU - Lee, Jae Kwan

AU - Kim, Jae Hoon

AU - Son, Sung Kyong

AU - Song, Eun Seop

AU - Lee, Kwang Beom

AU - Lee, Jung Pil

AU - Lee, Jong Min

AU - Yun, Young Mi

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Cervical cancer is one of the most common gynecological malignancies in Korea, although the incidence has been declining in recent years. This study explored whether antioxidant vitamin intakes influenced the risk of cervical cancer. The association between antioxidant vitamin intakes and cervical cancer risk was calculated for 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models. Cases reported statistically lower mean dietary intakes of vitamin A, β-carotene, and vitamin C than did controls. Total intakes of vitamins A and E, which included both dietary and supplement intake, were also lower in cases. Those patients in the highest quartiles of dietary vitamin A, β-carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, β-carotene, and vitamin C: odds ratio (OR) = 0.36 [95% confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI = 0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of vitamins A, C, and E were strongly inversely associated with cervical cancer risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53 (CI = 0.28-0.99), respectively. The findings support a role for increased antioxidant vitamin intake in decreasing the risk of cervical cancer. These associations need to be assessed in large prospective studies with long-term follow-up.

AB - Cervical cancer is one of the most common gynecological malignancies in Korea, although the incidence has been declining in recent years. This study explored whether antioxidant vitamin intakes influenced the risk of cervical cancer. The association between antioxidant vitamin intakes and cervical cancer risk was calculated for 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models. Cases reported statistically lower mean dietary intakes of vitamin A, β-carotene, and vitamin C than did controls. Total intakes of vitamins A and E, which included both dietary and supplement intake, were also lower in cases. Those patients in the highest quartiles of dietary vitamin A, β-carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, β-carotene, and vitamin C: odds ratio (OR) = 0.36 [95% confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI = 0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of vitamins A, C, and E were strongly inversely associated with cervical cancer risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53 (CI = 0.28-0.99), respectively. The findings support a role for increased antioxidant vitamin intake in decreasing the risk of cervical cancer. These associations need to be assessed in large prospective studies with long-term follow-up.

UR - http://www.scopus.com/inward/record.url?scp=76749164494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76749164494&partnerID=8YFLogxK

U2 - 10.1080/01635580903305326

DO - 10.1080/01635580903305326

M3 - Article

VL - 62

SP - 181

EP - 189

JO - Nutrition and Cancer

JF - Nutrition and Cancer

SN - 0163-5581

IS - 2

ER -