Integrated assessment of biomarker responses in common carp (Cyprinus carpio) exposed to perfluorinated organic compounds

Woo Keun Kim, Sung Kyu Lee, Jinho Jung

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

In this study, the toxicological effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) toward the common carp, Cyprinus carpio, were evaluated by assessing the responses of five biomarkers, including DNA single-strand breaks (COMET), vitellogenin (VTG) concentration, and the activities of 7-ethoxyresorufin-O-deethylase (EROD), acetylcholinesterase (AChE) and catalase (CAT). Upon PFOA exposure, both the VTG concentration and CAT activity were significantly increased, while there was a negligible change in the responses of other biomarkers when compared to the control. Upon PFOS exposure, a significant increase in the DNA single-strand breaks was observed, while the responses of other biomarkers were not significantly altered when compared to the control. Standardized scores of biomarker responses were visualized using star plots and computed as the integrated biomarker response (IBR). As expected from the different biomarker responses, PFOA and PFOS showed totally different patterns of star plots. Additionally, the IBR values were well correlated with the logarithmic concentrations of PFOA and PFOS (R2=0.9434 and 0.9511, respectively). These results suggest that the IBR might be a useful tool for quantification of various biomarker responses induced by toxic chemicals.

Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalJournal of Hazardous Materials
Volume180
Issue number1-3
DOIs
Publication statusPublished - 2010 Aug 1

Fingerprint

Carps
perfluorooctanoic acid
Biomarkers
Organic compounds
biomarker
organic compound
sulfonate
Vitellogenins
Single-Stranded DNA Breaks
Acids
acid
Catalase
Stars
DNA
Cytochrome P-450 CYP1A1
induced response
Poisons
Acetylcholinesterase
Toxicology
perfluorooctane sulfonic acid

Keywords

  • Aquatic toxicology
  • Integrated biomarker response
  • Perfluorooctane sulfonate
  • Perfluorooctanoic acid
  • Star plot

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Waste Management and Disposal
  • Environmental Chemistry
  • Environmental Engineering

Cite this

Integrated assessment of biomarker responses in common carp (Cyprinus carpio) exposed to perfluorinated organic compounds. / Kim, Woo Keun; Lee, Sung Kyu; Jung, Jinho.

In: Journal of Hazardous Materials, Vol. 180, No. 1-3, 01.08.2010, p. 395-400.

Research output: Contribution to journalArticle

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