Integrated photonic structures for parallel fluorescence and refractive index biosensing

Meredith M. Lee, Thomas D. O'Sullivan, Antonio Cerruto, Victor Liu, Jingyu Zhang, Ofer Levi, Heon Lee, Steven R J Brueck, Shanhui Fan, James S. Harris

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We present a multi-modality optical sensing platform employing integrated Vertical Cavity Surface Emitting Lasers (VCSELs), photodetectors, and filters suitable for portable, real-time analyte detection in aqueous environments. Fluorescence and refractive index sensors designed to utilize visible and near-infrared VCSELs for low background absorption from analyte delivery fluids are described. We demonstrate in vitro fluorescence sensing of Cy5.5 dye with a detection sensitivity of 5 nM and photonic crystal slab refractive index sensing with tunable GaAs-based 670 nm VCSELs. This compact, parallel sensor architecture enables multiplexed, cost-effective on-chip biosensing.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume8034
DOIs
Publication statusPublished - 2011 Jul 25
EventPhotonic Microdevices/Microstructures for Sensing III - Orlando, FL, United States
Duration: 2011 Apr 272011 Apr 28

Other

OtherPhotonic Microdevices/Microstructures for Sensing III
CountryUnited States
CityOrlando, FL
Period11/4/2711/4/28

Keywords

  • Biosensing
  • Fluorescence
  • Integrated
  • Lab-on-a-chip
  • Label free
  • Photonic crystal
  • Sensor
  • VCSEL

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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  • Cite this

    Lee, M. M., O'Sullivan, T. D., Cerruto, A., Liu, V., Zhang, J., Levi, O., Lee, H., Brueck, S. R. J., Fan, S., & Harris, J. S. (2011). Integrated photonic structures for parallel fluorescence and refractive index biosensing. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 8034). [803406] https://doi.org/10.1117/12.884228