TY - JOUR
T1 - Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies
AU - Pozdeyev, Nikita
AU - Yoo, Minjae
AU - Mackie, Ryan
AU - Schweppe, Rebecca E.
AU - Tan, Aik Choon
AU - Haugen, Bryan R.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - The consistency of in vitro drug sensitivity data is of key importance for cancer pharmacogenomics. Previous attempts to correlate drug sensitivities from the large pharmacogenomics databases, such as the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), have produced discordant results. We developed a new drug sensitivity metric, the area under the dose response curve adjusted for the range of tested drug concentrations, which allows integration of heterogeneous drug sensitivity data from the CCLE, the GDSC, and the Cancer Therapeutics Response Portal (CTRP). We show that there is moderate to good agreement of drug sensitivity data for many targeted therapies, particularly kinase inhibitors. The results of this largest cancer cell line drug sensitivity data analysis to date are accessible through the online portal, which serves as a platform for high power pharmacogenomics analysis.
AB - The consistency of in vitro drug sensitivity data is of key importance for cancer pharmacogenomics. Previous attempts to correlate drug sensitivities from the large pharmacogenomics databases, such as the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), have produced discordant results. We developed a new drug sensitivity metric, the area under the dose response curve adjusted for the range of tested drug concentrations, which allows integration of heterogeneous drug sensitivity data from the CCLE, the GDSC, and the Cancer Therapeutics Response Portal (CTRP). We show that there is moderate to good agreement of drug sensitivity data for many targeted therapies, particularly kinase inhibitors. The results of this largest cancer cell line drug sensitivity data analysis to date are accessible through the online portal, which serves as a platform for high power pharmacogenomics analysis.
KW - Cancer
KW - Cell line
KW - Database integration
KW - Drug sensitivity
KW - Pharmacogenomics
UR - http://www.scopus.com/inward/record.url?scp=84982290181&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982290181&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.10010
DO - 10.18632/oncotarget.10010
M3 - Article
C2 - 27322211
AN - SCOPUS:84982290181
VL - 7
SP - 51619
EP - 51625
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 32
ER -