Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Do Yeun Park, Jaeseo Lee, Justin J. Chung, Youngmee Jung, Soo Hyun Kim

Research output: Contribution to journalReview article

2 Citations (Scopus)


Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.

Original languageEnglish
JournalTrends in Biotechnology
Publication statusPublished - 2019 Jan 1


  • innervation-on-a-chip
  • integrated organ-on-a-chip
  • multiplexing
  • organ-on-chip
  • scaling rules
  • vascularization-on-a-chip

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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