Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis

Yu Sun, Xi Ying Fan, Dong Mei Cao, Wenqiang Tang, Kun He, Jia Ying Zhu, Jun Xian He, Ming Yi Bai, Shengwei Zhu, Eunkyoo Oh, Sunita Patil, Tae Wuk Kim, Hongkai Ji, Wing Hong Wong, Seung Y. Rhee, Zhi Yong Wang

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416 Citations (Scopus)

Abstract

Brassinosteroids (BRs) regulate a wide range of developmental and physiological processes in plants through a receptor-kinase signaling pathway that controls the BZR transcription factors. Here, we use transcript profiling and chromatin-immunoprecipitation microarray (ChIP-chip) experiments to identify 953 BR-regulated BZR1 target (BRBT) genes. Functional studies of selected BRBTs further demonstrate roles in BR promotion of cell elongation. The BRBT genes reveal numerous molecular links between the BR-signaling pathway and downstream components involved in developmental and physiological processes. Furthermore, the results reveal extensive crosstalk between BR and other hormonal and light-signaling pathways at multiple levels. For example, BZR1 not only controls the expression of many signaling components of other hormonal and light pathways but also coregulates common target genes with light-signaling transcription factors. Our results provide a genomic map of steroid hormone actions in plants that reveals a regulatory network that integrates hormonal and light-signaling pathways for plant growth regulation.

Original languageEnglish
Pages (from-to)765-777
Number of pages13
JournalDevelopmental Cell
Volume19
Issue number5
DOIs
Publication statusPublished - 2010 Nov 16
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Cite this

Sun, Y., Fan, X. Y., Cao, D. M., Tang, W., He, K., Zhu, J. Y., He, J. X., Bai, M. Y., Zhu, S., Oh, E., Patil, S., Kim, T. W., Ji, H., Wong, W. H., Rhee, S. Y., & Wang, Z. Y. (2010). Integration of Brassinosteroid Signal Transduction with the Transcription Network for Plant Growth Regulation in Arabidopsis. Developmental Cell, 19(5), 765-777. https://doi.org/10.1016/j.devcel.2010.10.010