Integration of multi-level biomarker responses to cadmium and benzo[k]fluoranthene in the pale chub (Zacco platypus)

Woo Keun Kim, Sung Kyu Lee, June Woo Park, Kyungho Choi, Jordan Cargo, Daniel Schlenk, Jinho Jung

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The Cd exposure for 14 days significantly increased both the molecular (DNA single-strand breaks) and biochemical (metallothionein concentrations) biomarkers in the freshwater pale chub, Zacco platypus, whereas changes in the histological and physiological biomarker responses were negligible. The B. kF exposure for 14 days led to significant increases in the mRNA expression of catalase and superoxide dismutase, 7-ethoxyresorufin-. O-deethylase enzymatic activity and DNA single-strand breakage at the molecular and biochemical levels. In addition, exposure to 50. μg/L of B. kF induced histological alteration in the liver, with significant changes to the liver somatic index and condition factor at the physiological level. The integration of multi-level biomarker responses at the molecular, biochemical and physiological levels was highly correlated with the concentrations of Cd and B. kF.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalEcotoxicology and Environmental Safety
Volume110
DOIs
Publication statusPublished - 2014 Aug 19

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Pollution

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