Integration of PDMS microfluidic channel with silicon- based electromechanical cantilever sensor on a CD chip

H. Cho, J. Kang, S. Kwak, K. Hwang, J. Min, J. Lee, Dae Sung Yoon, T. Kim

Research output: Contribution to journalConference article

3 Citations (Scopus)

Abstract

This paper reports a novel application of centrifugal microfluidic delivery to a highly sensitive electromechanical biosensor integrated on a single chip. The microfluidic channel was designed for label-free immunoassay of a micro cantilever sensor, which has extremely low limit of detection of PSA (prostate specific antigen) up to pico-molar concentration by measuring the change of resonant frequency after antibody-antigen interaction. This integration can reduce sample consumption and the number of experiment processes since no external pumping system is necessary. We demonstrate here the application of simple electrical detection for the specific PSA as an example of automatically sequential fluid delivery.

Original languageEnglish
Article numberWP10
Pages (from-to)698-701
Number of pages4
JournalProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Publication statusPublished - 2005 Oct 25
Externally publishedYes
Event18th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2005 Miami - Miami Beach, FL, United States
Duration: 2005 Jan 302005 Feb 3

Fingerprint

antigens
Silicon
Prostate-Specific Antigen
Antigens
Microfluidics
chips
sensors
delivery
Sensors
silicon
Biosensors
Labels
Natural frequencies
immunoassay
antibodies
bioinstrumentation
Antibodies
Fluids
resonant frequencies
pumping

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Integration of PDMS microfluidic channel with silicon- based electromechanical cantilever sensor on a CD chip. / Cho, H.; Kang, J.; Kwak, S.; Hwang, K.; Min, J.; Lee, J.; Yoon, Dae Sung; Kim, T.

In: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 25.10.2005, p. 698-701.

Research output: Contribution to journalConference article

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