Intense accumulation of 18F-FDG, not enhancement on MRI, helps to guide the surgical biopsy accurately in soft tissue tumors

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5 Citations (Scopus)

Abstract

Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [18F]-2-fluoro-2- deoxy-d-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.

Original languageEnglish
Pages (from-to)887-889
Number of pages3
JournalAnnals of Nuclear Medicine
Volume23
Issue number10
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Fluorodeoxyglucose F18
Sarcoma
Biopsy
Neoplasms
Positron-Emission Tomography
Necrosis
Glucose

Keywords

  • FDG PET
  • Metabolic biopsy
  • MR
  • Sarcoma
  • Soft tissue tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Intense accumulation of 18F-FDG, not enhancement on MRI, helps to guide the surgical biopsy accurately in soft tissue tumors",
abstract = "Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [18F]-2-fluoro-2- deoxy-d-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.",
keywords = "FDG PET, Metabolic biopsy, MR, Sarcoma, Soft tissue tumor",
author = "Park, {Jong Hoon} and Park, {Eun Kyung} and Kang, {Chang Ho} and Kim, {Chul Hwan} and Jae-Gol Choe and Won Noh",
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T1 - Intense accumulation of 18F-FDG, not enhancement on MRI, helps to guide the surgical biopsy accurately in soft tissue tumors

AU - Park, Jong Hoon

AU - Park, Eun Kyung

AU - Kang, Chang Ho

AU - Kim, Chul Hwan

AU - Choe, Jae-Gol

AU - Noh, Won

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [18F]-2-fluoro-2- deoxy-d-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.

AB - Soft tissue sarcomas are a highly heterogeneous group of malignancies that arise from mesenchymal tissues. Grading of soft tissue sarcomas is an important prerequisite for the choice of therapy and estimation of prognosis. However, incisional biopsy of huge soft tissue sarcoma lesions frequently fails to provide an accurate diagnosis when there is a benign component, cystic changes and/or necrosis. MRI is helpful in evaluating the extent of the sarcoma lesion, vascularization, invasiveness and integrity of surrounding tissue, but definitive differentiation of benignity and malignancy is not possible with it. In this study, positron emission tomography using [18F]-2-fluoro-2- deoxy-d-glucose successfully guided surgeons to identify the most hypermetabolic and, therefore, the most suitable biopsy sites of huge soft tissue sarcoma.

KW - FDG PET

KW - Metabolic biopsy

KW - MR

KW - Sarcoma

KW - Soft tissue tumor

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