Inter-Network High-Order Functional Connectivity (IN-HOFC) and its Alteration in Patients with Mild Cognitive Impairment

Han Zhang, Panteleimon Giannakopoulos, Sven Haller, Dinggang Shen, Seong Whan Lee, Shijun Qiu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Little is known about the high-order interactions among brain regions measured by the similarity of higher-order features (other than the raw blood-oxygen-level-dependent signals) which can characterize higher-level brain functional connectivity (FC). Previously, we proposed FC topographical profile-based high-order FC (HOFC) and found that this metric could provide supplementary information to traditional FC for early Alzheimer’s disease (AD) detection. However, whether such findings apply to network-level brain functional integration is unknown. In this paper, we propose an extended HOFC method, termed inter-network high-order FC (IN-HOFC), as a useful complement to the traditional inter-network FC methods, for characterizing more complex organizations among the large-scale brain networks. In the IN-HOFC, both network definition and inter-network FC are defined in a high-order manner. To test whether IN-HOFC is more sensitive to cognition decline due to brain diseases than traditional inter-network FC, 77 mild cognitive impairments (MCIs) and 89 controls are compared among the conventional methods and our IN-HOFC. The result shows that IN-HOFCs among three temporal lobe-related high-order networks are dampened in MCIs. The impairment of IN-HOFC is especially found between the anterior and posterior medial temporal lobe and could be a potential MCI biomarker at the network level. The competing network-level low-order FC methods, however, either revealing less or failing to detect any group difference. This work demonstrates the biological meaning and potential diagnostic value of the IN-HOFC in clinical neuroscience studies.

Original languageEnglish
JournalNeuroinformatics
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Alzheimer’s disease (AD)
  • Brain network
  • Functional connectivity
  • Functional magnetic resonance imaging (fMRI)
  • High-order
  • Mild cognitive impairment (MCI)

ASJC Scopus subject areas

  • Software
  • Neuroscience(all)
  • Information Systems

Fingerprint Dive into the research topics of 'Inter-Network High-Order Functional Connectivity (IN-HOFC) and its Alteration in Patients with Mild Cognitive Impairment'. Together they form a unique fingerprint.

  • Cite this