Interaction and assembly of HBV structural proteins: Novel target sites of anti-HBV agents

In Geol Choi, Yeon Gyu Yu

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Human hepatitis B virus (HBV) causes chronic hepatitis disease which is a major public health problem worldwide. HBV has 4 genes encoding viral DNA polymerase, protein X and two structural proteins, the surface and core proteins. HBV DNA polymerase has been a primary target for the development of anti-HBV agents due to its enzymatic nature, and several nucleoside derivatives that inhibit HBV polymerase are currently used as anti-HBV therapeutics. On the other hand, accumulating information on the capsid assembly and the maturation process of HBV particles provides additional approaches for the development of anti-HBV agents. Proper interaction between core proteins is required for assembly of the nucleocapsid, and the specificity of the interactions between the capsid and surface proteins is essential for the maturation of active HBV in infected cells. In this article, the assembly process of active HBV particles and approaches to utilize the interactions of HBV structural proteins as target site for the development of anti-HBV agents are reviewed. In particular, novel approaches to target the assembly process an the interaction between HBV structural proteins are introduced.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalInfectious Disorders - Drug Targets
Volume7
Issue number3
DOIs
Publication statusPublished - 2007 Sep

Keywords

  • Assembly inhibitor
  • Capsid assembly
  • Core protein
  • HBV
  • Surface protein

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Microbiology (medical)

Fingerprint Dive into the research topics of 'Interaction and assembly of HBV structural proteins: Novel target sites of anti-HBV agents'. Together they form a unique fingerprint.

  • Cite this