Interaction between brain-derived neurotrophic factor val66Met polymorphism and recent negative stressor in harm avoidance

Seog Ju Kim, Seong Jin Cho, Ha Min Jang, Jonghan Shin, Pil Whan Park, Yu Jin Lee, In Hee Cho, Jung Eun Choi, Heon-Jeong Lee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between BDNF Val66Met polymorphism and negative life stressors in HA. BDNF Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 ± 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the BDNF genotype and negative life stressors in HA (p = 0.02). Only subjects with the Val/Val genotype showed higher HA with recent negative stressors. Our finding suggests that BDNF Val66Met polymorphism might influence HA by interacting with recent negative stress experience.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalNeuropsychobiology
Volume61
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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Brain-Derived Neurotrophic Factor
Temperament
Epidemiologic Studies
Genotype
Depression
Equipment and Supplies
Interviews
Independent Living
Ego
Major Depressive Disorder
Diagnostic and Statistical Manual of Mental Disorders
Anxiety

Keywords

  • Brain-derived neurotrophic factor
  • Harm avoidance
  • Stressor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry

Cite this

Interaction between brain-derived neurotrophic factor val66Met polymorphism and recent negative stressor in harm avoidance. / Kim, Seog Ju; Cho, Seong Jin; Jang, Ha Min; Shin, Jonghan; Park, Pil Whan; Lee, Yu Jin; Cho, In Hee; Choi, Jung Eun; Lee, Heon-Jeong.

In: Neuropsychobiology, Vol. 61, No. 1, 01.01.2009, p. 19-26.

Research output: Contribution to journalArticle

Kim, Seog Ju ; Cho, Seong Jin ; Jang, Ha Min ; Shin, Jonghan ; Park, Pil Whan ; Lee, Yu Jin ; Cho, In Hee ; Choi, Jung Eun ; Lee, Heon-Jeong. / Interaction between brain-derived neurotrophic factor val66Met polymorphism and recent negative stressor in harm avoidance. In: Neuropsychobiology. 2009 ; Vol. 61, No. 1. pp. 19-26.
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