Interaction between obstructive sleep apnea and shortened telomere length on brain white matter abnormality

Kyung Mee Choi, Robert J. Thomas, Dai Wui Yoon, Seung Ku Lee, Inkyung Baik, Chol Shin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Study Objectives: Age-related brain white matter changes (WMC) have been associated separately with obstructive sleep apnea (OSA) and short telomere length (TL). No studies have examined their interaction effect on WMC. Methods: This is a cross-sectional study with a community-based sample of 420 participants (mean age, 61.3 ± 7.2) from the Korean Genome and Epidemiology Study during 2011-2012. An overnight fasted blood sample was taken to determine glucose and blood lipid levels at the sleep laboratory of Korea University Ansan Hospital. The status of brain WMC was determined using structural magnetic resonance imaging at 1.5 Tesla. Overnight polysomnography was performed, and leukocyte TL was measured. OSA was determined based on apnea-hypopnea index, and short TL was defined as the lowest quartile of the study participants. Results: Adjusting for age, sex, BMI, smoking, drinking, snoring, and hypertension, odds ratio (OR) of brain WMC was estimated using multivariate logistic regression. The odds ratio was significant for cardiovascular disease (OR, 4.5; 95% CI, 1.2-16.3) and OSA (OR, 4.0; 95% CI, 1.0-15.2) among those with short TL; and for diabetes (OR, 3.0; 95% CI, 1.3-13.0) and age (OR, 1.1; 95% CI, 1.0-1.1) among those with longer TL. Interaction effect of OSA and short TL (OR, 4.3; 95% CI, 1.4-13.8) was significant, compared to those with neither OSA nor short TL. Conclusions: This study provides a first evidence of mediated interaction of short TL with OSA on brain WMC in a community-based sample. The results generate new hypotheses regarding mechanisms of impaired brain health in sleep apnea.

Original languageEnglish
Pages (from-to)1639-1645
Number of pages7
JournalSleep
Volume39
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

Fingerprint

Telomere Shortening
Telomere
Obstructive Sleep Apnea
Odds Ratio
Brain
Snoring
White Matter
Polysomnography
Sleep Apnea Syndromes
Apnea
Korea
Drinking
Blood Glucose
Sleep
Epidemiology
Leukocytes
Cardiovascular Diseases
Cross-Sectional Studies
Logistic Models
Smoking

Keywords

  • Brain white matter changes
  • Sleep-disordered breathing
  • Telomere shortening

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

Cite this

Interaction between obstructive sleep apnea and shortened telomere length on brain white matter abnormality. / Choi, Kyung Mee; Thomas, Robert J.; Yoon, Dai Wui; Lee, Seung Ku; Baik, Inkyung; Shin, Chol.

In: Sleep, Vol. 39, No. 9, 01.09.2016, p. 1639-1645.

Research output: Contribution to journalArticle

Choi, Kyung Mee ; Thomas, Robert J. ; Yoon, Dai Wui ; Lee, Seung Ku ; Baik, Inkyung ; Shin, Chol. / Interaction between obstructive sleep apnea and shortened telomere length on brain white matter abnormality. In: Sleep. 2016 ; Vol. 39, No. 9. pp. 1639-1645.
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abstract = "Study Objectives: Age-related brain white matter changes (WMC) have been associated separately with obstructive sleep apnea (OSA) and short telomere length (TL). No studies have examined their interaction effect on WMC. Methods: This is a cross-sectional study with a community-based sample of 420 participants (mean age, 61.3 ± 7.2) from the Korean Genome and Epidemiology Study during 2011-2012. An overnight fasted blood sample was taken to determine glucose and blood lipid levels at the sleep laboratory of Korea University Ansan Hospital. The status of brain WMC was determined using structural magnetic resonance imaging at 1.5 Tesla. Overnight polysomnography was performed, and leukocyte TL was measured. OSA was determined based on apnea-hypopnea index, and short TL was defined as the lowest quartile of the study participants. Results: Adjusting for age, sex, BMI, smoking, drinking, snoring, and hypertension, odds ratio (OR) of brain WMC was estimated using multivariate logistic regression. The odds ratio was significant for cardiovascular disease (OR, 4.5; 95{\%} CI, 1.2-16.3) and OSA (OR, 4.0; 95{\%} CI, 1.0-15.2) among those with short TL; and for diabetes (OR, 3.0; 95{\%} CI, 1.3-13.0) and age (OR, 1.1; 95{\%} CI, 1.0-1.1) among those with longer TL. Interaction effect of OSA and short TL (OR, 4.3; 95{\%} CI, 1.4-13.8) was significant, compared to those with neither OSA nor short TL. Conclusions: This study provides a first evidence of mediated interaction of short TL with OSA on brain WMC in a community-based sample. The results generate new hypotheses regarding mechanisms of impaired brain health in sleep apnea.",
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AU - Thomas, Robert J.

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AU - Shin, Chol

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AB - Study Objectives: Age-related brain white matter changes (WMC) have been associated separately with obstructive sleep apnea (OSA) and short telomere length (TL). No studies have examined their interaction effect on WMC. Methods: This is a cross-sectional study with a community-based sample of 420 participants (mean age, 61.3 ± 7.2) from the Korean Genome and Epidemiology Study during 2011-2012. An overnight fasted blood sample was taken to determine glucose and blood lipid levels at the sleep laboratory of Korea University Ansan Hospital. The status of brain WMC was determined using structural magnetic resonance imaging at 1.5 Tesla. Overnight polysomnography was performed, and leukocyte TL was measured. OSA was determined based on apnea-hypopnea index, and short TL was defined as the lowest quartile of the study participants. Results: Adjusting for age, sex, BMI, smoking, drinking, snoring, and hypertension, odds ratio (OR) of brain WMC was estimated using multivariate logistic regression. The odds ratio was significant for cardiovascular disease (OR, 4.5; 95% CI, 1.2-16.3) and OSA (OR, 4.0; 95% CI, 1.0-15.2) among those with short TL; and for diabetes (OR, 3.0; 95% CI, 1.3-13.0) and age (OR, 1.1; 95% CI, 1.0-1.1) among those with longer TL. Interaction effect of OSA and short TL (OR, 4.3; 95% CI, 1.4-13.8) was significant, compared to those with neither OSA nor short TL. Conclusions: This study provides a first evidence of mediated interaction of short TL with OSA on brain WMC in a community-based sample. The results generate new hypotheses regarding mechanisms of impaired brain health in sleep apnea.

KW - Brain white matter changes

KW - Sleep-disordered breathing

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