Interaction of obstructive sleep apnoea and cognitive impairment with slow gait speed in middle-aged and older adults

Sunghee Lee, Chol Shin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: to investigate whether slow gait speed is associated with cognitive impairment and further whether the association is modified by obstructive sleep apnoea (OSA). Methods: in total, 2,222 adults aged 49-80 years, free from dementia, stroke and head injury were asked to walk a 4-m course at fast and usual gait speeds. The time taken to walk was measured. All participants completed the Korean Mini- Mental State Examination, which was validated in the Korean language, to assess cognitive function. Additionally, the participants completed a polysomnography test to ascertain OSA (defined as an apnoea-hypopnoea index ≥15). Multivariable linear regression models were utilised to test the associations. Results: time taken to walk 4 m showed significant inverse associations with cognitive scores (P value = 0.001 at fast gait speed and P = 0.002 at usual gait speed). Furthermore, a significant interaction according to OSA on the association between time to walk and cognitive impairment was found (P value for interaction = 0.003 at fast gait speed and P value for interaction = 0.007 at usual gait speed). Conclusion: we found that the inverse association between the time taken to walk 4 m and a cognitive score became significantly stronger, if an individual had OSA.

Original languageEnglish
Article numberafw228
Pages (from-to)653-659
Number of pages7
JournalAge and Ageing
Volume46
Issue number4
DOIs
Publication statusPublished - 2017 Jul 1

Keywords

  • Cognition
  • Gait
  • Obstructive sleep apnoea
  • Older people

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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