Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season

Ji Yun Noh, Sooyeon Lim, Joon-Young Song, Wonseok Choi, Hye Won Jeong, Jung Yeon Heo, Jacob Lee, Yu Bin Seo, Jin Soo Lee, Seong Heon Wie, Young Keun Kim, Kyung Hwa Park, Sook In Jung, Shin Woo Kim, Sun Hee Lee, Han Sol Lee, Young-Hoon Yoon, Hee-Jin Cheong, Woo Joo Kim

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12 Citations (Scopus)

Abstract

In the 2016-2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1% (95% confidence interval [CI], -147.2 to 6.4); -70.0% (95% CI, -212.0 to 7.4) in 19-64 years and 4.3% (95% CI, -137.8 to 61.5) in the elderly. Circulating A(H3N2) viruses belonged to the three phylogenetic subclades of 3C.2a, differently to A/Hong Kong/4801/2014, the current vaccine strain. Amino acid substitutions in hemagglutinin of circulating viruses seem to contribute to low VE. In conclusion, interim VE analysis presented that the protection of laboratory-confirmed influenza by seasonal influenza vaccination did not show the statistical significance in South Korea in the 2016-2017 influenza season.

Original languageEnglish
Article numbere0178010
JournalPLoS One
Volume12
Issue number5
DOIs
Publication statusPublished - 2017 May 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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    Noh, J. Y., Lim, S., Song, J-Y., Choi, W., Jeong, H. W., Heo, J. Y., Lee, J., Seo, Y. B., Lee, J. S., Wie, S. H., Kim, Y. K., Park, K. H., Jung, S. I., Kim, S. W., Lee, S. H., Lee, H. S., Yoon, Y-H., Cheong, H-J., & Kim, W. J. (2017). Interim estimates of the effectiveness of the influenza vaccine against A(H3N2) influenza in adults in South Korea, 2016-2017 season. PLoS One, 12(5), [e0178010]. https://doi.org/10.1371/journal.pone.0178010