Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis

Young Ho Lee, Hyo Jin Kim, Young Hee Rho, Sungjae Choi, Jong Dae Ji, Gwan Gyu Song

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The aim of this study was to evaluate the association of polymorphism in IL-1 receptor antagonist (IL-1RA) gene intron 2 with susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and their clinical features. Polymerase chain reaction of a genomic DNA was used to determine genotypes of the IL-1RA in 138 RA, 93 SLE, and 127 healthy control subjects. The frequency of IL-1RA allele 2 (IL-1RN*2) was lower in RA patients (2.5%) than in control subjects (7.1%) (odds ratio 0.34, 95% confidence interval 0.13-0.88, P = 0.02). There was a significant difference in genotype and allele distribution between RA patients and controls. However, it did not differ between SLE patients and controls. In SLE and RA patients, there was no significant difference in clinical and laboratory findings concerning IL-1RA polymorphisms. In conclusion, our data suggest that IL-1RA gene polymorphism is not responsible for specific clinical characteristics in RA and SLE but that IL-1RN*2 is relevant in the susceptibility to RA, suggesting a protective role of IL-1RN*2 in the pathogenesis of RA.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalRheumatology International
Volume24
Issue number3
DOIs
Publication statusPublished - 2004 May 1

Fingerprint

Interleukin-1 Receptors
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Genes
Interleukin-2
Alleles
Genotype
Introns
Healthy Volunteers
Odds Ratio
Confidence Intervals
Polymerase Chain Reaction
DNA

Keywords

  • IL-1 receptor antagonist polymorphism
  • Rheumatoid arthritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis. / Lee, Young Ho; Kim, Hyo Jin; Rho, Young Hee; Choi, Sungjae; Ji, Jong Dae; Song, Gwan Gyu.

In: Rheumatology International, Vol. 24, No. 3, 01.05.2004, p. 133-136.

Research output: Contribution to journalArticle

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